Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 770727..771381 Replicon chromosome
Accession NZ_CP056597
Organism Citrobacter freundii strain RHBSTW-00334

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV164_RS03780 Protein ID WP_181540418.1
Coordinates 770974..771381 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV164_RS03775 Protein ID WP_096755798.1
Coordinates 770727..770993 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV164_RS03750 765941..767374 - 1434 WP_115257538.1 6-phospho-beta-glucosidase BglA -
HV164_RS03755 767495..768223 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HV164_RS03760 768276..768587 + 312 WP_181540417.1 N(4)-acetylcytidine aminohydrolase -
HV164_RS03765 768751..769410 + 660 WP_096755796.1 hemolysin III family protein -
HV164_RS03770 769490..770470 - 981 WP_115257540.1 tRNA-modifying protein YgfZ -
HV164_RS03775 770727..770993 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV164_RS03780 770974..771381 + 408 WP_181540418.1 protein YgfX Toxin
HV164_RS03785 771427..771948 - 522 WP_096755800.1 flavodoxin FldB -
HV164_RS03790 772061..772957 + 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HV164_RS03795 772981..773694 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV164_RS03800 773700..775433 + 1734 WP_181625702.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15945.97 Da        Isoelectric Point: 11.2851

>T163762 WP_181540418.1 NZ_CP056597:770974-771381 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPPMQK

Download         Length: 408 bp

>T163762 NZ_CP072762:c2891633-2891238 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT163762 WP_096755798.1 NZ_CP056597:770727-770993 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163762 NZ_CP072762:c2891875-2891630 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References