163759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4703654..4704320 Replicon chromosome
Accession NZ_CP056595
Organism Citrobacter freundii strain RHBSTW-00342

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HV167_RS22635 Protein ID WP_071696338.1
Coordinates 4703961..4704320 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HV167_RS22630 Protein ID WP_071696337.1
Coordinates 4703654..4703971 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV167_RS22595 4698783..4699277 + 495 WP_003031646.1 mannose/fructose/sorbose PTS transporter subunit IIB -
HV167_RS22600 4699343..4700140 + 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
HV167_RS22605 4700152..4700976 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV167_RS22610 4701044..4702267 + 1224 WP_071696334.1 L-sorbose 1-phosphate reductase -
HV167_RS22615 4702269..4703081 + 813 WP_071696335.1 shikimate 5-dehydrogenase -
HV167_RS22620 4703126..4703458 - 333 WP_071696336.1 hypothetical protein -
HV167_RS22625 4703366..4703644 + 279 WP_008324306.1 putative addiction module antidote protein -
HV167_RS22630 4703654..4703971 - 318 WP_071696337.1 helix-turn-helix domain-containing protein Antitoxin
HV167_RS22635 4703961..4704320 - 360 WP_071696338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV167_RS22640 4704534..4705223 + 690 WP_003841421.1 dipeptidase PepE -
HV167_RS22645 4705289..4706920 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13491.50 Da        Isoelectric Point: 10.1224

>T163759 WP_071696338.1 NZ_CP056595:c4704320-4703961 [Citrobacter freundii]
MTKPLYWVGHAWKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVAGKATPKPEIDLIYQRIKAAQRHAQESGYVT

Download         Length: 360 bp

>T163759 NZ_CP072762:c2876197-2875778 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11494.41 Da        Isoelectric Point: 9.0005

>AT163759 WP_071696337.1 NZ_CP056595:c4703971-4703654 [Citrobacter freundii]
MSHEVEASSGNVYADLGVYDAEQMQLKAQLAMVIGEILQRKGLTQQQSAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT163759 NZ_CP072762:c2876418-2876194 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References