163758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yafW/CbtA-CbeA
Location 4563082..4563875 Replicon chromosome
Accession NZ_CP056595
Organism Citrobacter freundii strain RHBSTW-00342

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag HV167_RS21985 Protein ID WP_000854726.1
Coordinates 4563498..4563875 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A837Z892
Locus tag HV167_RS21980 Protein ID WP_057688277.1
Coordinates 4563082..4563408 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV167_RS21950 4558736..4559044 + 309 Protein_4305 transcriptional regulator -
HV167_RS21955 4559055..4561451 + 2397 Protein_4306 autotransporter domain-containing protein -
HV167_RS21960 4561542..4561781 + 240 WP_001115184.1 DUF905 domain-containing protein -
HV167_RS21965 4561883..4562341 + 459 WP_032655093.1 antirestriction protein -
HV167_RS21970 4562357..4562833 + 477 WP_057688276.1 RadC family protein -
HV167_RS21975 4562842..4563063 + 222 WP_000691994.1 DUF987 domain-containing protein -
HV167_RS21980 4563082..4563408 + 327 WP_057688277.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV167_RS21985 4563498..4563875 + 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
HV167_RS21990 4563872..4564359 + 488 Protein_4313 hypothetical protein -
HV167_RS21995 4564371..4564568 + 198 WP_000839269.1 DUF957 domain-containing protein -
HV167_RS22000 4564653..4565495 + 843 WP_001548928.1 DUF4942 domain-containing protein -
HV167_RS22005 4566067..4567728 + 1662 WP_003036606.1 fatty acid--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T163758 WP_000854726.1 NZ_CP056595:4563498-4563875 [Citrobacter freundii]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T163758 NZ_CP072762:2829821-2830246 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12166.79 Da        Isoelectric Point: 7.6921

>AT163758 WP_057688277.1 NZ_CP056595:4563082-4563408 [Citrobacter freundii]
MSNPTRGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 327 bp

>AT163758 NZ_CP072762:2829594-2829815 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure
AlphaFold DB A0A837Z892

References