Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4720721..4721352 Replicon chromosome
Accession NZ_CP056592
Organism Citrobacter freundii strain RHBSTW-00350

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag HV171_RS22855 Protein ID WP_003837806.1
Coordinates 4721077..4721352 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag HV171_RS22850 Protein ID WP_003837808.1
Coordinates 4720721..4721080 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV171_RS22825 4716407..4716964 + 558 WP_003837816.1 DcrB family lipoprotein -
HV171_RS22830 4716968..4718185 - 1218 WP_071696361.1 MFS transporter -
HV171_RS22835 4718467..4719516 + 1050 WP_003023393.1 AI-2E family transporter -
HV171_RS22840 4719579..4720157 + 579 WP_061547458.1 4'-phosphopantetheinyl transferase AcpT -
HV171_RS22845 4720207..4720608 + 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
HV171_RS22850 4720721..4721080 - 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV171_RS22855 4721077..4721352 - 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
HV171_RS22860 4721430..4722554 - 1125 WP_048213609.1 ABC transporter permease -
HV171_RS22865 4722554..4725301 - 2748 WP_048218800.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T163741 WP_003837806.1 NZ_CP056592:c4721352-4721077 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T163741 NZ_CP072762:c1388984-1388691 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT163741 WP_003837808.1 NZ_CP056592:c4721080-4720721 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT163741 NZ_CP072762:c1389250-1388981 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References