Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 381004..381670 Replicon chromosome
Accession NZ_CP056592
Organism Citrobacter freundii strain RHBSTW-00350

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HV171_RS01885 Protein ID WP_071696338.1
Coordinates 381004..381363 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HV171_RS01890 Protein ID WP_071696337.1
Coordinates 381353..381670 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV171_RS01875 378404..380035 + 1632 WP_003031618.1 Na/Pi cotransporter family protein -
HV171_RS01880 380101..380790 - 690 WP_003841421.1 dipeptidase PepE -
HV171_RS01885 381004..381363 + 360 WP_071696338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV171_RS01890 381353..381670 + 318 WP_071696337.1 helix-turn-helix domain-containing protein Antitoxin
HV171_RS01895 381680..381958 - 279 WP_008324306.1 putative addiction module antidote protein -
HV171_RS01900 381866..382198 + 333 WP_071696336.1 hypothetical protein -
HV171_RS01905 382243..383055 - 813 WP_071696335.1 shikimate 5-dehydrogenase -
HV171_RS01910 383057..384280 - 1224 WP_071696334.1 L-sorbose 1-phosphate reductase -
HV171_RS01915 384348..385172 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV171_RS01920 385184..385981 - 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
HV171_RS01925 386047..386541 - 495 WP_003031646.1 mannose/fructose/sorbose PTS transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13491.50 Da        Isoelectric Point: 10.1224

>T163727 WP_071696338.1 NZ_CP056592:381004-381363 [Citrobacter freundii]
MTKPLYWVGHAWKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVAGKATPKPEIDLIYQRIKAAQRHAQESGYVT

Download         Length: 360 bp

>T163727 NZ_CP072762:703489-703890 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11494.41 Da        Isoelectric Point: 9.0005

>AT163727 WP_071696337.1 NZ_CP056592:381353-381670 [Citrobacter freundii]
MSHEVEASSGNVYADLGVYDAEQMQLKAQLAMVIGEILQRKGLTQQQSAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT163727 NZ_CP072762:703247-703492 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References