Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 883016..883670 Replicon chromosome
Accession NZ_CP056573
Organism Citrobacter freundii strain RHBSTW-00370

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HV178_RS04305 Protein ID WP_003026936.1
Coordinates 883263..883670 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HV178_RS04300 Protein ID WP_003026938.1
Coordinates 883016..883282 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV178_RS04275 878216..879649 - 1434 WP_003846391.1 6-phospho-beta-glucosidase BglA -
HV178_RS04280 879771..880499 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HV178_RS04285 880552..880863 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
HV178_RS04290 881026..881685 + 660 WP_003838267.1 hemolysin III family protein -
HV178_RS04295 881779..882759 - 981 WP_048232745.1 tRNA-modifying protein YgfZ -
HV178_RS04300 883016..883282 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
HV178_RS04305 883263..883670 + 408 WP_003026936.1 protein YgfX Toxin
HV178_RS04310 883715..884236 - 522 WP_003026933.1 flavodoxin FldB -
HV178_RS04315 884350..885246 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
HV178_RS04320 885275..885988 + 714 WP_181553672.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV178_RS04325 885994..887727 + 1734 WP_048232743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T163704 WP_003026936.1 NZ_CP056573:883263-883670 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T163704 NZ_CP072761:2978791-2979231 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT163704 WP_003026938.1 NZ_CP056573:883016-883282 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163704 NZ_CP072761:2978517-2978804 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References