Detailed information of TA system TA163699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4759566..4760385
• Replicon: chromosome
• Accession: NZ_CP056567
• Organism: Klebsiella oxytoca strain RHBSTW-00373

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: HV180_RS22600
• Protein ID: WP_004110819.1
• Coordinates: 4760128..4760385 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HV180_RS22595
• Protein ID: WP_142447550.1
• Coordinates: 4759566..4760117 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV180_RS22575	4754945..4755625	+	681	WP_142447551.1	nitroreductase	-
HV180_RS22580	4755633..4756835	-	1203	WP_023320374.1	multidrug effflux MFS transporter	-
HV180_RS22585	4757541..4757792	-	252	WP_004110826.1	hypothetical protein	-
HV180_RS22590	4757920..4759548	-	1629	WP_142447657.1	SAM-dependent methyltransferase	-
HV180_RS22595	4759566..4760117	-	552	WP_142447550.1	N-acetyltransferase	Antitoxin
HV180_RS22600	4760128..4760385	-	258	WP_004110819.1	YjhX family toxin	Toxin
HV180_RS22605	4760967..4762151	+	1185	WP_004099225.1	mannonate dehydratase	-
HV180_RS22610	4762226..4763701	+	1476	WP_004110817.1	fructuronate reductase	-
HV180_RS22615	4763837..4764613	+	777	WP_004099223.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T163699 WP_004110819.1 NZ_CP056567:c4760385-4760128 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T163699 NZ_CP072761:2856757-2857182 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20260.15 Da
• Isoelectric Point: 6.5672

>AT163699 WP_142447550.1 NZ_CP056567:c4760117-4759566 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPRLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHAAYYPRHGFEPCAGDEGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT163699 NZ_CP072761:2856530-2856751 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2