Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1406565..1407350 Replicon chromosome
Accession NZ_CP056567
Organism Klebsiella oxytoca strain RHBSTW-00373

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV180_RS06955 Protein ID WP_142447844.1
Coordinates 1406565..1406939 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV180_RS06960 Protein ID WP_142447843.1
Coordinates 1406991..1407350 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV180_RS06930 1401582..1401986 + 405 WP_004114661.1 hypothetical protein -
HV180_RS06935 1401983..1403749 + 1767 WP_142447845.1 cell envelope biogenesis protein TolA -
HV180_RS06940 1403739..1404276 - 538 Protein_1364 PTS transporter subunit EIIC -
HV180_RS06945 1404507..1405073 - 567 WP_077267739.1 GNAT family N-acetyltransferase -
HV180_RS06950 1406037..1406258 + 222 WP_131135761.1 hypothetical protein -
HV180_RS06955 1406565..1406939 - 375 WP_142447844.1 TA system toxin CbtA family protein Toxin
HV180_RS06960 1406991..1407350 - 360 WP_142447843.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV180_RS06965 1407373..1407593 - 221 Protein_1369 DUF987 domain-containing protein -
HV180_RS06970 1407590..1408057 - 468 Protein_1370 DNA repair protein RadC -
HV180_RS06975 1408072..1408491 - 420 Protein_1371 antirestriction protein -
HV180_RS06980 1408749..1408967 + 219 WP_142447842.1 hypothetical protein -
HV180_RS06985 1409043..1411703 + 2661 WP_142447841.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1403813..1431872 28059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13886.81 Da        Isoelectric Point: 9.9565

>T163689 WP_142447844.1 NZ_CP056567:c1406939-1406565 [Klebsiella oxytoca]
MQTQRLSSTGETSPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQKHIEAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQPPFIGNIDMLRARKATGLMTRRGYKTVTDITGGRFSGGK

Download         Length: 375 bp

>T163689 NZ_CP072761:c2197903-2197574 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13064.93 Da        Isoelectric Point: 5.4552

>AT163689 WP_142447843.1 NZ_CP056567:c1407350-1406991 [Klebsiella oxytoca]
MQNTTNVANHDIAEPWWGLKPTVTPCFGARLVQEGNCLYYLTDRASITGTFSDADLRHLNQAFPLLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCDADTLGSCGYVYIALYPTPATTA

Download         Length: 360 bp

>AT163689 NZ_CP072761:c2198277-2197900 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References