Detailed information of TA system TA163689

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1406565..1407350
• Replicon: chromosome
• Accession: NZ_CP056567
• Organism: Klebsiella oxytoca strain RHBSTW-00373

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HV180_RS06955
• Protein ID: WP_142447844.1
• Coordinates: 1406565..1406939 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV180_RS06960
• Protein ID: WP_142447843.1
• Coordinates: 1406991..1407350 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV180_RS06930	1401582..1401986	+	405	WP_004114661.1	hypothetical protein	-
HV180_RS06935	1401983..1403749	+	1767	WP_142447845.1	cell envelope biogenesis protein TolA	-
HV180_RS06940	1403739..1404276	-	538	Protein_1364	PTS transporter subunit EIIC	-
HV180_RS06945	1404507..1405073	-	567	WP_077267739.1	GNAT family N-acetyltransferase	-
HV180_RS06950	1406037..1406258	+	222	WP_131135761.1	hypothetical protein	-
HV180_RS06955	1406565..1406939	-	375	WP_142447844.1	TA system toxin CbtA family protein	Toxin
HV180_RS06960	1406991..1407350	-	360	WP_142447843.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV180_RS06965	1407373..1407593	-	221	Protein_1369	DUF987 domain-containing protein	-
HV180_RS06970	1407590..1408057	-	468	Protein_1370	DNA repair protein RadC	-
HV180_RS06975	1408072..1408491	-	420	Protein_1371	antirestriction protein	-
HV180_RS06980	1408749..1408967	+	219	WP_142447842.1	hypothetical protein	-
HV180_RS06985	1409043..1411703	+	2661	WP_142447841.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1403813..1431872	28059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13886.81 Da
• Isoelectric Point: 9.9565

>T163689 WP_142447844.1 NZ_CP056567:c1406939-1406565 [Klebsiella oxytoca]
MQTQRLSSTGETSPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQKHIEAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQPPFIGNIDMLRARKATGLMTRRGYKTVTDITGGRFSGGK

Nucleotide

• Length: 375 bp

>T163689 NZ_CP072761:c2197903-2197574 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13064.93 Da
• Isoelectric Point: 5.4552

>AT163689 WP_142447843.1 NZ_CP056567:c1407350-1406991 [Klebsiella oxytoca]
MQNTTNVANHDIAEPWWGLKPTVTPCFGARLVQEGNCLYYLTDRASITGTFSDADLRHLNQAFPLLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCDADTLGSCGYVYIALYPTPATTA

Nucleotide

• Length: 360 bp

>AT163689 NZ_CP072761:c2198277-2197900 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA