Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 932343..933000 Replicon chromosome
Accession NZ_CP056567
Organism Klebsiella oxytoca strain RHBSTW-00373

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag HV180_RS04610 Protein ID WP_004105559.1
Coordinates 932590..933000 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag HV180_RS04605 Protein ID WP_004105561.1
Coordinates 932343..932609 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV180_RS04590 927596..928021 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
HV180_RS04595 928142..930940 - 2799 WP_142448279.1 transcriptional regulator DagR -
HV180_RS04600 931116..932099 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
HV180_RS04605 932343..932609 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
HV180_RS04610 932590..933000 + 411 WP_004105559.1 protein YgfX Toxin
HV180_RS04615 933009..933530 - 522 WP_004105557.1 flavodoxin FldB -
HV180_RS04620 933652..934548 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
HV180_RS04625 934571..935284 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV180_RS04630 935290..937023 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T163688 WP_004105559.1 NZ_CP056567:932590-933000 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T163688 NZ_CP072761:1969489-1969737 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT163688 WP_004105561.1 NZ_CP056567:932343-932609 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163688 NZ_CP072761:1969277-1969489 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References