Detailed information of TA system TA163687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 675556..676148
• Replicon: chromosome
• Accession: NZ_CP056567
• Organism: Klebsiella oxytoca strain RHBSTW-00373

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: HV180_RS03325
• Protein ID: WP_016808034.1
• Coordinates: 675774..676148 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A2J4YM08
• Locus tag: HV180_RS03320
• Protein ID: WP_004105957.1
• Coordinates: 675556..675777 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV180_RS03300	671117..671671	+	555	WP_004105965.1	YgjV family protein	-
HV180_RS03305	671686..672933	-	1248	WP_004105963.1	serine/threonine transporter SstT	-
HV180_RS03310	673188..674156	-	969	WP_142447679.1	TerC family protein	-
HV180_RS03315	674407..675396	-	990	WP_064351610.1	Gfo/Idh/MocA family oxidoreductase	-
HV180_RS03320	675556..675777	+	222	WP_004105957.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HV180_RS03325	675774..676148	+	375	WP_016808034.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HV180_RS03330	676128..676631	-	504	WP_142447680.1	M48 family metallopeptidase	-
HV180_RS03335	676710..678353	-	1644	WP_049591522.1	glycoside hydrolase family 43 protein	-
HV180_RS03340	678482..679348	-	867	WP_004105950.1	AraC family transcriptional regulator	-
HV180_RS03345	679456..680799	+	1344	WP_023321663.1	glycoside-pentoside-hexuronide (GPH):cation symporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (2-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13835.89 Da
• Isoelectric Point: 6.0752

>T163687 WP_016808034.1 NZ_CP056567:675774-676148 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHCEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Nucleotide

• Length: 375 bp

>T163687 NZ_CP072761:c1948991-1948602 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8185.19 Da
• Isoelectric Point: 5.7996

>AT163687 WP_004105957.1 NZ_CP056567:675556-675777 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Nucleotide

• Length: 222 bp

>AT163687 NZ_CP072761:c1949215-1948988 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2J4YM08