163682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3563781..3564401 Replicon chromosome
Accession NZ_CP056559
Organism Citrobacter freundii strain RHBSTW-00408

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV186_RS17055 Protein ID WP_002892050.1
Coordinates 3564183..3564401 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HV186_RS17050 Protein ID WP_115259201.1
Coordinates 3563781..3564155 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV186_RS17040 3558927..3560120 + 1194 WP_096758038.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV186_RS17045 3560143..3563292 + 3150 WP_096758039.1 efflux RND transporter permease AcrB -
HV186_RS17050 3563781..3564155 + 375 WP_115259201.1 Hha toxicity modulator TomB Antitoxin
HV186_RS17055 3564183..3564401 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV186_RS17060 3564783..3565256 + 474 WP_096758041.1 YlaC family protein -
HV186_RS17065 3565330..3565470 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HV186_RS17070 3565472..3565732 - 261 WP_115259215.1 type B 50S ribosomal protein L31 -
HV186_RS17075 3565917..3567470 + 1554 WP_115259216.1 EAL domain-containing protein -
HV186_RS17080 3567524..3567877 - 354 WP_115259217.1 DUF1428 family protein -
HV186_RS17085 3567960..3568571 - 612 WP_153879388.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163682 WP_002892050.1 NZ_CP056559:3564183-3564401 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163682 NZ_CP072761:c1388984-1388691 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14454.26 Da        Isoelectric Point: 5.5653

>AT163682 WP_115259201.1 NZ_CP056559:3563781-3564155 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT163682 NZ_CP072761:c1389250-1388981 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References