Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2351737..2352506 Replicon chromosome
Accession NZ_CP056559
Organism Citrobacter freundii strain RHBSTW-00408

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV186_RS11105 Protein ID WP_181490189.1
Coordinates 2352024..2352506 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV186_RS11100 Protein ID WP_168246960.1
Coordinates 2351737..2352033 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV186_RS11085 2347237..2348424 + 1188 WP_135912045.1 outer membrane protein transport protein -
HV186_RS11090 2348704..2349333 + 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HV186_RS11095 2349642..2351624 + 1983 WP_117342783.1 MBL fold metallo-hydrolase -
HV186_RS11100 2351737..2352033 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HV186_RS11105 2352024..2352506 + 483 WP_181490189.1 GNAT family N-acetyltransferase Toxin
HV186_RS11110 2352668..2353459 - 792 WP_181490190.1 SDR family oxidoreductase -
HV186_RS11115 2353608..2354501 + 894 WP_181490191.1 LysR family transcriptional regulator -
HV186_RS11120 2354536..2354820 - 285 Protein_2178 aldo/keto reductase -
HV186_RS11125 2355271..2356320 + 1050 WP_181597118.1 NAD(P)-dependent alcohol dehydrogenase -
HV186_RS11130 2356593..2357384 + 792 Protein_2180 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17740.35 Da        Isoelectric Point: 8.4643

>T163681 WP_181490189.1 NZ_CP056559:2352024-2352506 [Citrobacter freundii]
MEINVTAPALLTEGHDLQPFNCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSYGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T163681 NZ_CP072761:1384541-1384972 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT163681 WP_168246960.1 NZ_CP056559:2351737-2352033 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT163681 NZ_CP072761:1384284-1384544 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References