Detailed information of TA system TA163671

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 842870..843596
• Replicon: chromosome
• Accession: NZ_CP056559
• Organism: Citrobacter freundii strain RHBSTW-00408

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HV186_RS04200
• Protein ID: WP_050873731.1
• Coordinates: 843273..843596 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV186_RS04195
• Protein ID: WP_181597030.1
• Coordinates: 842870..843205 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV186_RS04165	838547..839326	+	780	WP_181597027.1	glycine betaine ABC transporter substrate-binding protein	-
HV186_RS04170	839387..840199	-	813	WP_120066456.1	DoxX family protein	-
HV186_RS04175	840230..840778	-	549	WP_120066455.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
HV186_RS04180	841646..842110	+	465	WP_120066454.1	antirestriction protein	-
HV186_RS04185	842122..842622	+	501	WP_181597028.1	DNA repair protein RadC	-
HV186_RS04190	842632..842853	+	222	WP_181597029.1	DUF987 domain-containing protein	-
HV186_RS04195	842870..843205	+	336	WP_181597030.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV186_RS04200	843273..843596	+	324	WP_050873731.1	TA system toxin CbtA family protein	Toxin
HV186_RS04205	843999..844355	+	357	Protein_824	DUF4102 domain-containing protein	-
HV186_RS04210	844394..845296	-	903	WP_181597031.1	LysR family transcriptional regulator	-
HV186_RS04215	845426..846418	+	993	WP_181597032.1	zinc-dependent alcohol dehydrogenase family protein	-
HV186_RS04220	846474..846974	+	501	WP_181597033.1	alcohol dehydrogenase catalytic domain-containing protein	-
HV186_RS04225	846944..847747	-	804	Protein_828	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-106)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12281.01 Da
• Isoelectric Point: 6.0641

>T163671 WP_050873731.1 NZ_CP056559:843273-843596 [Citrobacter freundii]
MQISTVPATVPVSSRLSPMQVWQQLLTYLLEHHYGLTLNDTPFHDGAAIEEHIDAGITLADAINFLVEKYELVRIDRKGF
TWQEQTPYLTTIDIMRARRALSNLNRN

Nucleotide

• Length: 324 bp

>T163671 NZ_CP072761:718285-718692 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12651.35 Da
• Isoelectric Point: 6.3669

>AT163671 WP_181597030.1 NZ_CP056559:842870-843205 [Citrobacter freundii]
MHNNDATEWGLRRDITPRFGARLVQEGHRLHFLADRAGFTGMFSEVQALQLDEAFPHFVAHLELMLLSCELNPRYAHCVT
LYRSGLTCEADTLGSHGYIYIAIYPTNQVKD

Nucleotide

• Length: 336 bp

>AT163671 NZ_CP072761:718028-718288 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA