163669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 721265..722043 Replicon chromosome
Accession NZ_CP056559
Organism Citrobacter freundii strain RHBSTW-00408

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag HV186_RS03580 Protein ID WP_181490967.1
Coordinates 721555..722043 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag HV186_RS03575 Protein ID WP_181490966.1
Coordinates 721265..721558 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV186_RS03555 717520..718617 + 1098 WP_181490963.1 type VI secretion system baseplate subunit TssG -
HV186_RS03560 718592..719125 + 534 WP_181490964.1 type VI secretion system lipoprotein TssJ -
HV186_RS03565 719125..719568 + 444 WP_137362186.1 type VI secretion system baseplate subunit TssE -
HV186_RS03570 719570..720940 + 1371 WP_181490965.1 type VI secretion system ImpA family N-terminal domain-containing protein -
HV186_RS03575 721265..721558 + 294 WP_181490966.1 DUF1778 domain-containing protein Antitoxin
HV186_RS03580 721555..722043 + 489 WP_181490967.1 GNAT family N-acetyltransferase Toxin
HV186_RS03585 722181..723007 - 827 Protein_703 IS3 family transposase -
HV186_RS03595 723358..724065 - 708 WP_096755730.1 DUF554 domain-containing protein -
HV186_RS03600 724534..726669 + 2136 WP_117342646.1 ornithine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - vipA/tssB 713834..722043 8209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17663.58 Da        Isoelectric Point: 7.2657

>T163669 WP_181490967.1 NZ_CP056559:721555-722043 [Citrobacter freundii]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTASGRFRRNMPDPI
PVVVLGRLAVDQSLHGRGIGRALIRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVE
SI

Download         Length: 489 bp

>T163669 NZ_CP072761:711009-711410 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10890.53 Da        Isoelectric Point: 6.3782

>AT163669 WP_181490966.1 NZ_CP056559:721265-721558 [Citrobacter freundii]
MPATNSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLALLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT163669 NZ_CP072761:710785-711012 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References