Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4085664..4086321 Replicon chromosome
Accession NZ_CP056552
Organism Enterobacter sp. RHBSTW-00422

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag HV189_RS19920 Protein ID WP_014171514.1
Coordinates 4085664..4086074 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV189_RS19925 Protein ID WP_003863437.1
Coordinates 4086055..4086321 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV189_RS19900 4081662..4083395 - 1734 WP_050737267.1 single-stranded-DNA-specific exonuclease RecJ -
HV189_RS19905 4083401..4084114 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV189_RS19910 4084138..4085034 - 897 WP_050737268.1 site-specific tyrosine recombinase XerD -
HV189_RS19915 4085136..4085657 + 522 WP_014171513.1 flavodoxin FldB -
HV189_RS19920 4085664..4086074 - 411 WP_014171514.1 protein YgfX Toxin
HV189_RS19925 4086055..4086321 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV189_RS19930 4086616..4087596 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
HV189_RS19935 4087705..4088364 - 660 WP_014171517.1 hemolysin III family protein -
HV189_RS19940 4088631..4089362 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
HV189_RS19945 4089479..4090912 + 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T163666 WP_014171514.1 NZ_CP056552:c4086074-4085664 [Enterobacter sp. RHBSTW-00422]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T163666 NZ_CP072761:c695234-694842 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT163666 WP_003863437.1 NZ_CP056552:c4086321-4086055 [Enterobacter sp. RHBSTW-00422]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT163666 NZ_CP072761:c695488-695231 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References