Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1110664..1111284 Replicon chromosome
Accession NZ_CP056552
Organism Enterobacter sp. RHBSTW-00422

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag HV189_RS05415 Protein ID WP_014168902.1
Coordinates 1110664..1110882 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag HV189_RS05420 Protein ID WP_020885187.1
Coordinates 1110910..1111284 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV189_RS05385 1106675..1106935 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
HV189_RS05390 1106938..1107078 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV189_RS05395 1107075..1107785 - 711 WP_020885191.1 GNAT family N-acetyltransferase -
HV189_RS05400 1107886..1109346 + 1461 WP_050737454.1 PLP-dependent aminotransferase family protein -
HV189_RS05405 1109318..1109785 - 468 WP_032677533.1 membrane protein -
HV189_RS05410 1109903..1110454 - 552 WP_020885188.1 maltose O-acetyltransferase -
HV189_RS05415 1110664..1110882 - 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
HV189_RS05420 1110910..1111284 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
HV189_RS05425 1111796..1114942 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
HV189_RS05430 1114965..1116158 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T163657 WP_014168902.1 NZ_CP056552:c1110882-1110664 [Enterobacter sp. RHBSTW-00422]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T163657 NZ_CP072743:51423-51710 [Serratia fonticola]
ATGACTTATAAGATTGACTTTGACAATGCAGCCTTCAAAGAGTGGAAAAAATTAGGTGAGACTGTACGTCAACAGTTAAA
AAAGAAGCTGGCACAGATTGTTGAGGCGCCACGCGTTGAGGCTAACCGACTACACTCTTTACCTGATTGCTATAAGATCA
AACTACGCGCATCCGGTTATCGGCTAGTTTACAAGGTCGAAGATGAAACGGTTGTGATCCTCGTCCTTGCTGTAGGTAAA
CGCGAACGGCTGGAGGTTTATAAAGCAGCCGCCACAAGGTTGAGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT163657 WP_020885187.1 NZ_CP056552:c1111284-1110910 [Enterobacter sp. RHBSTW-00422]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT163657 NZ_CP072743:51191-51433 [Serratia fonticola]
ATGGGTACAATGAACATTCGTATCGACGATGATTTAAAGGCCCGGGCAGGGGTAGCGCTCGACGGATTGGGGATCACAGC
CTCGGAGGCTGTACGTCTGGTGCTTGAATACATTGCACAAAATAACCGCCTTCCGGTTCAGGTGGCATTACTGGCTGATG
AAGACGCAGATATCATCGAACTGGCGCGTGAACGTCTGGCTAATCCTGGCAAACGGATCCGAGTAACACTCGATGACTTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References