Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4392395..4392971 Replicon chromosome
Accession NZ_CP056546
Organism Citrobacter sp. RHBSTW-00424

Toxin (Protein)


Gene name shpA Uniprot ID A0A2I8S420
Locus tag HV191_RS21350 Protein ID WP_049269953.1
Coordinates 4392684..4392971 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A2I8S1U6
Locus tag HV191_RS21345 Protein ID WP_016155614.1
Coordinates 4392395..4392697 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV191_RS21320 4387665..4387859 + 195 WP_003830038.1 YbdD/YjiX family protein -
HV191_RS21325 4387872..4388828 + 957 WP_049040419.1 GTPase -
HV191_RS21330 4389015..4390589 + 1575 Protein_4185 AAA family ATPase -
HV191_RS21340 4391809..4392087 + 279 Protein_4187 ATP-binding domain-containing protein -
HV191_RS21345 4392395..4392697 - 303 WP_016155614.1 BrnA antitoxin family protein Antitoxin
HV191_RS21350 4392684..4392971 - 288 WP_049269953.1 BrnT family toxin Toxin
HV191_RS21355 4393203..4394369 + 1167 WP_019078303.1 restriction endonuclease -
HV191_RS21360 4394432..4394572 - 141 WP_165500049.1 hypothetical protein -
HV191_RS21365 4394535..4394833 + 299 Protein_4192 type I addiction module toxin, SymE family -
HV191_RS21370 4394964..4395455 - 492 WP_016151575.1 type VI secretion system tube protein Hcp -
HV191_RS21375 4395456..4395962 - 507 WP_047414535.1 hypothetical protein -
HV191_RS21380 4395962..4396324 - 363 WP_046275905.1 DUF2778 domain-containing protein -
HV191_RS21385 4396599..4397663 - 1065 WP_049041982.1 DUF2955 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(42-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11433.87 Da        Isoelectric Point: 8.6051

>T163652 WP_049269953.1 NZ_CP056546:c4392971-4392684 [Citrobacter sp. RHBSTW-00424]
MPMEFEWDANKAQSNHRKHGVRFEDAILVFDDPQHLSRQERYENGEYRWQTIGLVHGIVVILVAHSVRFESRFEVIRIIS
ARKADRKERNRYEHS

Download         Length: 288 bp

>T163652 NZ_CP072742:2871673-2872095 [Serratia fonticola]
GTGGCCCTGTGGCGATGTGATGTCCGCGTTTCCTGGCGTACCCAGTTAGTCTCGTTGCTGACTCACGGCCTGCTGATTTT
GCTGATCCTGATCGCCCCGTGGCCGGAAGGCTATGGCCCGATCTGGTTGGTGCTGTTGACGTTGGTGGTGTTTGAGTGCA
TTCGTAGCCAAAAGCGCATTGCATCCAGGCAGGGAGAACTGCGGTTGCTGGCTGAACGCCGGATTGAGTGGCATGGCCGA
GAATGGCTGATGGTGAACAAGCCCTGGATGCCTGGGTTCGGTATTTTGCTGTCGCTTCAGCAGATCGACGGCAAGAAACG
CCATCGGCTGTGGTTGGCTTCGGATTCCATGAGCAAAGCGGATTGGCGCCAACTGCGTCAACGGTTGTCGTTTGAACAAT
CCGCTACCGATGAGGACGTATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11466.12 Da        Isoelectric Point: 10.1293

>AT163652 WP_016155614.1 NZ_CP056546:c4392697-4392395 [Citrobacter sp. RHBSTW-00424]
MSIVKHKRGSVSALSAQHEAELKALANKPDDDIDYSDIPVTEDKQWSEAIRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT163652 NZ_CP072742:2871426-2871692 [Serratia fonticola]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGCGAGTTGGATATCTCGATCATGCCGTT
TTTCGAACATGAATACGATACGCTGAGTGATGCAGACAAGGCCGTATTCATCCGCTTGCTCGAATGTGACGACCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGATCAAGATCTGCAGAGAATGGTGTCCCTGATCCAAATGCGAAAT
AAAGCCCGTGGCCCTGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S420

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8S1U6

References