Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3814126..3814746 Replicon chromosome
Accession NZ_CP056546
Organism Citrobacter sp. RHBSTW-00424

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV191_RS18650 Protein ID WP_002892050.1
Coordinates 3814528..3814746 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag HV191_RS18645 Protein ID WP_003021733.1
Coordinates 3814126..3814500 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV191_RS18635 3809273..3810466 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV191_RS18640 3810489..3813638 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
HV191_RS18645 3814126..3814500 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
HV191_RS18650 3814528..3814746 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV191_RS18655 3814927..3815478 + 552 WP_103283555.1 maltose O-acetyltransferase -
HV191_RS18660 3815595..3816065 + 471 WP_016152071.1 YlaC family protein -
HV191_RS18665 3816143..3816283 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HV191_RS18670 3816285..3816545 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
HV191_RS18675 3816734..3818287 + 1554 WP_047416867.1 EAL domain-containing protein -
HV191_RS18680 3818339..3818692 - 354 WP_003831033.1 DUF1428 family protein -
HV191_RS18685 3818757..3819386 - 630 WP_103283554.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163650 WP_002892050.1 NZ_CP056546:3814528-3814746 [Citrobacter sp. RHBSTW-00424]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163650 NZ_CP072742:1774718-1775059 [Serratia fonticola]
ATGGATGCTATATTTGTTGAGTTAAGTATTTTTGAAGCGAAGCGTGCTGATTATCTTTCCGATGATGAATTCAAGACATT
CCAGCAGATGCTGCTGATTAATCCATTCTGCGGTGATGTTATCCAGCACACTGGCGGGTTAAGGAAGGTCAGATTTGCGG
ATCACCGTCGTGGAAAAGGTAAACGAGGTGGCTTGCGGGTGATCTATTATTGGTGGCTTGAAAAGTCTCACTTTTTGCTT
TTTGTCATTTACGACAAAGACAAAAAAGATGACCTTAGCCGCAACGAGCGCGAGATGCTGCGTAGGATGTTGGAAATTTT
GAAACAAGGGGGCACCTTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT163650 WP_003021733.1 NZ_CP056546:3814126-3814500 [Citrobacter sp. RHBSTW-00424]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT163650 NZ_CP072742:1775056-1775370 [Serratia fonticola]
ATGAGCGAACTCAGCCTTTTTGAAGAACTCTCCCAGGGAATGAAAGACTGGAGTGATTACAATGAGGGTAAAATCACGCT
TAAAACCCACGCCATATCACTGAAAAAAAACATATCTATGTCACCAGACGAGTTAAAAGCAATACGTGAAAAACTGCGTC
TTTCACAAGCCGTTTTTGCGGATTACTTGCATACCGGTGTCACTACTTATCAAAACTGGGAACAGGGCAGAGCCAAACCC
AACAAACAGGCACTTCTTTTGATCCGTATGGTTGAAAAAGACCCCATGACGCTGGATACGTTAGCTGCCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References