Detailed information of TA system TA163628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2669842..2671430
• Replicon: chromosome
• Accession: NZ_CP056530
• Organism: Klebsiella pneumoniae strain RHBSTW-00433

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W8UI36
• Locus tag: HV193_RS13160
• Protein ID: WP_002904792.1
• Coordinates: 2669842..2671164 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV193_RS13165
• Protein ID: WP_004176198.1
• Coordinates: 2671164..2671430 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV193_RS13145	2664898..2667399	+	2502	WP_048981966.1	fimbrial biogenesis outer membrane usher protein	-
HV193_RS13150	2667387..2668391	+	1005	WP_004184029.1	type 1 fimbrial protein	-
HV193_RS13155	2668533..2669825	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HV193_RS13160	2669842..2671164	-	1323	WP_002904792.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV193_RS13165	2671164..2671430	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HV193_RS13170	2671817..2672143	-	327	WP_048981965.1	hydroxyisourate hydrolase	-
HV193_RS13175	2672140..2672640	-	501	WP_048981964.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HV193_RS13180	2672618..2673997	-	1380	WP_004176204.1	purine permease	-
HV193_RS13185	2674343..2675497	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HV193_RS13190	2675478..2676401	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T163628 WP_002904792.1 NZ_CP056530:c2671164-2669842 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T163628 NZ_CP072707:1478691-1478957 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT163628 WP_004176198.1 NZ_CP056530:c2671430-2671164 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT163628 NZ_CP072707:1478428-1478691 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A0E1CEC8