Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814121..814778 Replicon chromosome
Accession NZ_CP056530
Organism Klebsiella pneumoniae strain RHBSTW-00433

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV193_RS04085 Protein ID WP_002916310.1
Coordinates 814368..814778 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV193_RS04080 Protein ID WP_002916312.1
Coordinates 814121..814387 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV193_RS04055 809798..810766 - 969 WP_072269234.1 IS5 family transposase -
HV193_RS04060 810881..811609 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV193_RS04065 811659..811970 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HV193_RS04070 812134..812793 + 660 WP_002916317.1 hemolysin III family protein -
HV193_RS04075 812892..813875 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
HV193_RS04080 814121..814387 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV193_RS04085 814368..814778 + 411 WP_002916310.1 protein YgfX Toxin
HV193_RS04090 814785..815306 - 522 WP_004144730.1 flavodoxin FldB -
HV193_RS04095 815407..816303 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV193_RS04100 816326..817039 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV193_RS04105 817045..818778 + 1734 WP_060415880.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T163618 WP_002916310.1 NZ_CP056530:814368-814778 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T163618 NZ_CP072689:c2295451-2295275 [Escherichia marmotae]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT163618 WP_002916312.1 NZ_CP056530:814121-814387 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163618 NZ_CP072689:c2295229-2294813 [Escherichia marmotae]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCCGAAGCGTTGAC
GCAGGGAGAAACGGTCGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAACTCATCCCGTTACCTTCGCCATTGAATAACAACGATCACTTTATTGAAGTACCTTTAAGTGTTGCTTCTAAGGTA
TTGCTGCTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References