Detailed information of TA system TA163610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4502960..4503495
• Replicon: chromosome
• Accession: NZ_CP056515
• Organism: Citrobacter freundii strain RHBSTW-00444

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV198_RS21250
• Protein ID: WP_117343582.1
• Coordinates: 4503208..4503495 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4BKM9
• Locus tag: HV198_RS21245
• Protein ID: WP_006688247.1
• Coordinates: 4502960..4503211 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV198_RS21215	4497972..4498820	+	849	WP_135912711.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
HV198_RS21220	4498817..4499575	+	759	WP_115259672.1	phosphonate C-P lyase system protein PhnK	-
HV198_RS21225	4499684..4500364	+	681	WP_181506309.1	phosphonate C-P lyase system protein PhnL	-
HV198_RS21230	4500361..4501497	+	1137	WP_096758663.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
HV198_RS21235	4501500..4502045	+	546	WP_181506310.1	ribose 1,5-bisphosphokinase	-
HV198_RS21240	4502118..4502876	+	759	WP_181506311.1	phosphonate metabolism protein PhnP	-
HV198_RS21245	4502960..4503211	+	252	WP_006688247.1	plasmid stabilization protein	Antitoxin
HV198_RS21250	4503208..4503495	+	288	WP_117343582.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV198_RS21255	4503492..4503821	-	330	WP_096758667.1	hypothetical protein	-
HV198_RS21260	4503890..4506154	-	2265	WP_181506312.1	hybrid sensor histidine kinase/response regulator	-
HV198_RS21265	4506269..4507792	+	1524	WP_181506313.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11139.00 Da
• Isoelectric Point: 10.2830

>T163610 WP_117343582.1 NZ_CP056515:4503208-4503495 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDKTIQQQLAKELKKCGENPHVPSAKLRGIKDCYKIQLRTSRFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Nucleotide

• Length: 288 bp

>T163610 NZ_CP072689:379165-379338 [Escherichia marmotae]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTCTCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGCCTGCCCGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 4.2965

>AT163610 WP_006688247.1 NZ_CP056515:4502960-4503211 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT163610 NZ_CP072689:378842-379138 [Escherichia marmotae]
ATGGAAGGTATAAACAGGTTCAAAACTTACGTTGTTTCTTTTGATTATCCATCATCTTATTACTCAGTTTTCTTAAGGTT
AAGGTCGTTAATGTATGATATGGATTTCTCCTCTATAGTTGCTGATGAATATGGAATACCACGACAATTGAATGAGAATG
CTTTCGCAATAACGACATCATTAGCCGCAAGTGAAATTGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCAGATATT
GATTTTGACCTCAACATTATGATAGTCGATGACTATTTCCGTCAGTTCTACAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X1BT32