Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2453074..2453843 Replicon chromosome
Accession NZ_CP056515
Organism Citrobacter freundii strain RHBSTW-00444

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV198_RS11420 Protein ID WP_135912047.1
Coordinates 2453361..2453843 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV198_RS11415 Protein ID WP_168246960.1
Coordinates 2453074..2453370 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV198_RS11400 2448574..2449761 + 1188 WP_146716827.1 outer membrane protein transport protein -
HV198_RS11405 2450041..2450670 + 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HV198_RS11410 2450979..2452961 + 1983 WP_181507029.1 MBL fold metallo-hydrolase -
HV198_RS11415 2453074..2453370 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HV198_RS11420 2453361..2453843 + 483 WP_135912047.1 GNAT family N-acetyltransferase Toxin
HV198_RS11425 2453989..2454795 - 807 WP_181506995.1 SDR family oxidoreductase -
HV198_RS11430 2454944..2455837 + 894 WP_181506996.1 LysR family transcriptional regulator -
HV198_RS11435 2455872..2456861 - 990 WP_181506997.1 aldo/keto reductase -
HV198_RS11440 2456888..2457178 - 291 Protein_2241 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17755.36 Da        Isoelectric Point: 7.8926

>T163606 WP_135912047.1 NZ_CP056515:2453361-2453843 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSYGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T163606 NZ_CP072688:3717418-3717636 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT163606 WP_168246960.1 NZ_CP056515:2453074-2453370 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT163606 NZ_CP072688:3717018-3717392 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References