Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 906501..907155 Replicon chromosome
Accession NZ_CP056515
Organism Citrobacter freundii strain RHBSTW-00444

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV198_RS04405 Protein ID WP_096755799.1
Coordinates 906748..907155 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV198_RS04400 Protein ID WP_096755798.1
Coordinates 906501..906767 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV198_RS04375 901716..903149 - 1434 WP_115257538.1 6-phospho-beta-glucosidase BglA -
HV198_RS04380 903270..903998 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HV198_RS04385 904051..904362 + 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
HV198_RS04390 904526..905185 + 660 WP_096755796.1 hemolysin III family protein -
HV198_RS04395 905264..906244 - 981 WP_181506588.1 tRNA-modifying protein YgfZ -
HV198_RS04400 906501..906767 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV198_RS04405 906748..907155 + 408 WP_096755799.1 protein YgfX Toxin
HV198_RS04410 907201..907722 - 522 WP_096755800.1 flavodoxin FldB -
HV198_RS04415 907835..908731 + 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HV198_RS04420 908755..909468 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV198_RS04425 909474..911207 + 1734 WP_115257543.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T163597 WP_096755799.1 NZ_CP056515:906748-907155 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T163597 NZ_CP072688:1956255-1956506 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT163597 WP_096755798.1 NZ_CP056515:906501-906767 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163597 NZ_CP072688:1956503-1956757 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References