Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 837032..837810 Replicon chromosome
Accession NZ_CP056515
Organism Citrobacter freundii strain RHBSTW-00444

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag HV198_RS04045 Protein ID WP_181506573.1
Coordinates 837322..837810 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag HV198_RS04040 Protein ID WP_181506572.1
Coordinates 837032..837325 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV198_RS04025 833616..834575 + 960 WP_181506571.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
HV198_RS04030 834572..835441 + 870 Protein_790 SUMF1/EgtB/PvdO family nonheme iron enzyme -
HV198_RS04035 835419..836708 + 1290 WP_181507012.1 type VI secretion system ImpA family N-terminal domain-containing protein -
HV198_RS04040 837032..837325 + 294 WP_181506572.1 DUF1778 domain-containing protein Antitoxin
HV198_RS04045 837322..837810 + 489 WP_181506573.1 GNAT family N-acetyltransferase Toxin
HV198_RS04050 837948..838774 - 827 Protein_794 IS3 family transposase -
HV198_RS04060 839124..839831 - 708 WP_181506574.1 DUF554 domain-containing protein -
HV198_RS04065 840300..842435 + 2136 WP_115257507.1 ornithine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17762.68 Da        Isoelectric Point: 7.2658

>T163596 WP_181506573.1 NZ_CP056515:837322-837810 [Citrobacter freundii]
MISAPEPLHAGHILTPFCCGVDSMDNWLQQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTASGRFRRNMPDPI
PVVVLGRLAVDQSLHGRRIGRALIRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVE
SI

Download         Length: 489 bp

>T163596 NZ_CP072688:1182830-1183141 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10903.53 Da        Isoelectric Point: 8.6141

>AT163596 WP_181506572.1 NZ_CP056515:837032-837325 [Citrobacter freundii]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT163596 NZ_CP072688:1183138-1183557 [Escherichia coli]
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References