163595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 744003..744756 Replicon chromosome
Accession NZ_CP056515
Organism Citrobacter freundii strain RHBSTW-00444

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag HV198_RS03600 Protein ID WP_025799003.1
Coordinates 744379..744756 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag HV198_RS03595 Protein ID WP_072269511.1
Coordinates 744003..744329 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV198_RS03575 739411..742566 + 3156 WP_077267777.1 AIDA repeat-containing protein -
HV198_RS03580 742789..743220 + 432 WP_088903392.1 antirestriction protein -
HV198_RS03585 743232..743711 + 480 WP_025798999.1 DNA repair protein RadC -
HV198_RS03590 743725..743946 + 222 WP_045888217.1 DUF987 domain-containing protein -
HV198_RS03595 744003..744329 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV198_RS03600 744379..744756 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
HV198_RS03605 744753..745244 + 492 WP_045888216.1 hypothetical protein -
HV198_RS03610 745273..745476 + 204 WP_025799007.1 DUF957 domain-containing protein -
HV198_RS03615 745558..746403 + 846 WP_025799009.1 DUF4942 domain-containing protein -
HV198_RS03625 746706..747212 + 507 WP_181506553.1 G/U mismatch-specific DNA glycosylase -
HV198_RS03630 747258..749102 - 1845 WP_096755616.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T163595 WP_025799003.1 NZ_CP056515:744379-744756 [Citrobacter freundii]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T163595 NZ_CP072688:960329-960736 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT163595 WP_072269511.1 NZ_CP056515:744003-744329 [Citrobacter freundii]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT163595 NZ_CP072688:960082-960348 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References