163594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 646309..646849 Replicon chromosome
Accession NZ_CP056515
Organism Citrobacter freundii strain RHBSTW-00444

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV198_RS03140 Protein ID WP_181506521.1
Coordinates 646529..646849 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV198_RS03135 Protein ID WP_181506520.1
Coordinates 646309..646461 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV198_RS03115 641689..642363 + 675 WP_181506517.1 hypothetical protein -
HV198_RS03120 642704..643930 - 1227 WP_181506518.1 dNTP triphosphohydrolase -
HV198_RS03125 644318..645181 + 864 WP_181506519.1 GTPase family protein -
HV198_RS03130 645275..646006 + 732 Protein_611 DUF945 domain-containing protein -
HV198_RS03135 646309..646461 + 153 WP_181506520.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV198_RS03140 646529..646849 + 321 WP_181506521.1 TA system toxin CbtA family protein Toxin
HV198_RS03145 646963..647796 + 834 WP_181507005.1 DUF4942 domain-containing protein -
HV198_RS03150 648147..648992 + 846 WP_181506522.1 hypothetical protein -
HV198_RS03155 648995..649318 + 324 WP_111987026.1 SEC-C domain-containing protein -
HV198_RS03160 649414..650427 - 1014 WP_181506523.1 tyrosine-type recombinase/integrase -
HV198_RS03165 650427..651014 - 588 WP_181507006.1 phage repressor protein CI -
HV198_RS03170 651130..651393 + 264 WP_001630878.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(1-45)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12150.85 Da        Isoelectric Point: 6.4795

>T163594 WP_181506521.1 NZ_CP056515:646529-646849 [Citrobacter freundii]
MQISTVPATLPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHNESAIREHIEAGITLADALNFLVERYELIRTDRKGF
TWQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

>T163594 NZ_CP072688:c827045-826668 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCATACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5547.35 Da        Isoelectric Point: 5.4769

>AT163594 WP_181506520.1 NZ_CP056515:646309-646461 [Citrobacter freundii]
MELMLLSGELNPRCGHCVTLYRNGLTCEADTLGSHGYVYIAIYPSNQVKD

Download         Length: 153 bp

>AT163594 NZ_CP072688:c827466-827092 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGGCCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References