Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 4509270..4510908 | Replicon | chromosome |
| Accession | NZ_CP056505 | ||
| Organism | Citrobacter freundii strain RHBSTW-00449 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | HV201_RS22055 | Protein ID | WP_061548423.1 |
| Coordinates | 4509270..4510598 (-) | Length | 443 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | HV201_RS22060 | Protein ID | WP_072291329.1 |
| Coordinates | 4510603..4510908 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV201_RS22035 | 4505241..4506731 | + | 1491 | WP_061548418.1 | chromosome partitioning protein ParB | - |
| HV201_RS22040 | 4506715..4507254 | + | 540 | WP_061548419.1 | DUF2857 domain-containing protein | - |
| HV201_RS22045 | 4507273..4508406 | + | 1134 | WP_061548420.1 | helix-turn-helix domain-containing protein | - |
| HV201_RS22050 | 4508472..4509143 | - | 672 | WP_000863683.1 | hypothetical protein | - |
| HV201_RS22055 | 4509270..4510598 | - | 1329 | WP_061548423.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HV201_RS22060 | 4510603..4510908 | - | 306 | WP_072291329.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HV201_RS22065 | 4511459..4512108 | + | 650 | Protein_4333 | AIDA repeat-containing protein | - |
| HV201_RS22070 | 4512292..4513368 | + | 1077 | WP_181522655.1 | type II toxin-antitoxin system RnlA family toxin | - |
| HV201_RS22075 | 4513361..4513732 | + | 372 | WP_181522656.1 | type II toxin-antitoxin system RnlB family antitoxin | - |
| HV201_RS22080 | 4514308..4515006 | + | 699 | WP_181522657.1 | TIGR03761 family integrating conjugative element protein | - |
| HV201_RS22085 | 4514996..4515490 | + | 495 | WP_181522658.1 | DUF3158 family protein | - |
| HV201_RS22090 | 4515539..4515814 | - | 276 | WP_061548156.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 4502509..4571426 | 68917 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 443 a.a. Molecular weight: 50642.29 Da Isoelectric Point: 5.0388
>T163587 WP_061548423.1 NZ_CP056505:c4510598-4509270 [Citrobacter freundii]
MRRTQQRLAIWMNGLRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELTGLGRRQVESMMDDI
ISNTPEVIERVSTLLPESFPPELAECIFEGMRQQCRRLAGRE
MRRTQQRLAIWMNGLRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELTGLGRRQVESMMDDI
ISNTPEVIERVSTLLPESFPPELAECIFEGMRQQCRRLAGRE
Download Length: 1329 bp
>T163587 NZ_CP072687:c2972391-2972011 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11391.08 Da Isoelectric Point: 10.1481
>AT163587 WP_072291329.1 NZ_CP056505:c4510908-4510603 [Citrobacter freundii]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLTSGPQILSSM
SSSTMEESEQQKDSPARREKW
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLTSGPQILSSM
SSSTMEESEQQKDSPARREKW
Download Length: 306 bp
>AT163587 NZ_CP072687:c2972812-2972438 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|