Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4464780..4465356 Replicon chromosome
Accession NZ_CP056505
Organism Citrobacter freundii strain RHBSTW-00449

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag HV201_RS21840 Protein ID WP_003019170.1
Coordinates 4465069..4465356 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag HV201_RS21835 Protein ID WP_003019167.1
Coordinates 4464780..4465082 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV201_RS21820 4461292..4463442 + 2151 WP_048219778.1 pyruvate/proton symporter BtsT -
HV201_RS21825 4463553..4463747 + 195 WP_003830038.1 YbdD/YjiX family protein -
HV201_RS21830 4463760..4464716 + 957 WP_003019163.1 GTPase -
HV201_RS21835 4464780..4465082 - 303 WP_003019167.1 BrnA antitoxin family protein Antitoxin
HV201_RS21840 4465069..4465356 - 288 WP_003019170.1 BrnT family toxin Toxin
HV201_RS21845 4465509..4466573 - 1065 WP_048219780.1 DUF2955 domain-containing protein -
HV201_RS21850 4466563..4467630 - 1068 WP_032948464.1 HlyD family secretion protein -
HV201_RS21855 4467637..4468101 - 465 WP_003019178.1 MarR family transcriptional regulator -
HV201_RS21860 4468249..4468413 - 165 WP_003019180.1 DUF1127 domain-containing protein -
HV201_RS21865 4468591..4470003 + 1413 WP_003019183.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11157.53 Da        Isoelectric Point: 7.0746

>T163586 WP_003019170.1 NZ_CP056505:c4465356-4465069 [Citrobacter freundii]
MPMEFEWDANKAQSNLRKHGVRFEDAVLVFDDPQHLSRQDRHENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

>T163586 NZ_CP072687:2765508-2765615 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11462.06 Da        Isoelectric Point: 10.1293

>AT163586 WP_003019167.1 NZ_CP056505:c4465082-4464780 [Citrobacter freundii]
MSMVKHKRGSVSALSAQHEAELKALANKSDDDIDYSDIPVTEDKQWSEATRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT163586 NZ_CP072687:c2765455-2765394 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References