Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2731033..2731559 | Replicon | chromosome |
| Accession | NZ_CP056505 | ||
| Organism | Citrobacter freundii strain RHBSTW-00449 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HV201_RS13275 | Protein ID | WP_000323025.1 |
| Coordinates | 2731033..2731320 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HV201_RS13280 | Protein ID | WP_000534858.1 |
| Coordinates | 2731320..2731559 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV201_RS13230 | 2726057..2726272 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| HV201_RS13235 | 2727026..2727241 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HV201_RS13240 | 2727542..2727754 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HV201_RS13245 | 2727809..2727898 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| HV201_RS13250 | 2728176..2728928 | - | 753 | WP_001047135.1 | antitermination protein | - |
| HV201_RS13255 | 2728942..2729991 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| HV201_RS13260 | 2729993..2730271 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| HV201_RS13265 | 2730338..2730589 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| HV201_RS13270 | 2730806..2730961 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HV201_RS13275 | 2731033..2731320 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HV201_RS13280 | 2731320..2731559 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HV201_RS13285 | 2731584..2731889 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| HV201_RS13290 | 2732092..2732424 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| HV201_RS13295 | 2732861..2734201 | - | 1341 | WP_000589010.1 | ISNCY family transposase | - |
| HV201_RS13300 | 2734235..2734654 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| HV201_RS13305 | 2734695..2735660 | - | 966 | WP_000054506.1 | hypothetical protein | - |
| HV201_RS13310 | 2735641..2736162 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| HV201_RS13315 | 2736146..2736376 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2694934..2751948 | 57014 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T163583 WP_000323025.1 NZ_CP056505:c2731320-2731033 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T163583 NZ_CP072687:2229148-2229250 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT163583 WP_000534858.1 NZ_CP056505:c2731559-2731320 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT163583 NZ_CP072687:c2229288-2229020 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|