Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1630780..1631444 Replicon chromosome
Accession NZ_CP056505
Organism Citrobacter freundii strain RHBSTW-00449

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV201_RS07775 Protein ID WP_180208558.1
Coordinates 1630780..1631106 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV201_RS07780 Protein ID WP_047363623.1
Coordinates 1631127..1631444 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV201_RS07760 1626922..1627461 - 540 WP_003839289.1 DUF2058 domain-containing protein -
HV201_RS07765 1627835..1629733 + 1899 WP_003845056.1 methyl-accepting chemotaxis protein -
HV201_RS07770 1629908..1630537 + 630 WP_032936546.1 DNA-binding protein -
HV201_RS07775 1630780..1631106 - 327 WP_180208558.1 TA system toxin CbtA family protein Toxin
HV201_RS07780 1631127..1631444 - 318 WP_047363623.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV201_RS07785 1631465..1631686 - 222 WP_047363621.1 DUF987 domain-containing protein -
HV201_RS07790 1631695..1632171 - 477 WP_000811693.1 RadC family protein -
HV201_RS07795 1632187..1632645 - 459 WP_000211838.1 antirestriction protein -
HV201_RS07800 1632743..1632982 - 240 WP_000194654.1 DUF905 domain-containing protein -
HV201_RS07805 1633059..1633526 - 468 WP_001547765.1 hypothetical protein -
HV201_RS07810 1633549..1633992 - 444 WP_001547764.1 phage transcriptional regulator -
HV201_RS07815 1633992..1634228 - 237 WP_001144031.1 hypothetical protein -
HV201_RS07820 1634269..1634969 - 701 Protein_1530 WYL domain-containing protein -
HV201_RS07825 1635186..1636007 - 822 WP_047363676.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12347.29 Da        Isoelectric Point: 8.0567

>T163573 WP_180208558.1 NZ_CP056505:c1631106-1630780 [Citrobacter freundii]
MKTLPATISRATKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYIRAVDILRARQTLGLLRGSH

Download         Length: 327 bp

>T163573 NZ_CP072686:4268234-4268572 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12130.81 Da        Isoelectric Point: 7.8418

>AT163573 WP_047363623.1 NZ_CP056505:c1631444-1631127 [Citrobacter freundii]
MTHITWGLQRNITPRLGARLVQERNRLHYLADRASITGKFSDAEYRKLDETFPHFIRQMESMLTTAELSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT163573 NZ_CP072686:c4268239-4268163 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References