Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3576631..3577251 Replicon chromosome
Accession NZ_CP056473
Organism Citrobacter freundii strain RHBSTW-00477

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV211_RS17025 Protein ID WP_002892050.1
Coordinates 3577033..3577251 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HV211_RS17020 Protein ID WP_115259201.1
Coordinates 3576631..3577005 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV211_RS17010 3571777..3572970 + 1194 WP_096758038.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV211_RS17015 3572993..3576142 + 3150 WP_096758039.1 efflux RND transporter permease AcrB -
HV211_RS17020 3576631..3577005 + 375 WP_115259201.1 Hha toxicity modulator TomB Antitoxin
HV211_RS17025 3577033..3577251 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV211_RS17030 3577633..3578106 + 474 WP_181631498.1 YlaC family protein -
HV211_RS17035 3578180..3578320 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HV211_RS17040 3578322..3578582 - 261 WP_115259215.1 type B 50S ribosomal protein L31 -
HV211_RS17045 3578767..3580320 + 1554 WP_181631499.1 EAL domain-containing protein -
HV211_RS17050 3580374..3580727 - 354 WP_115259217.1 DUF1428 family protein -
HV211_RS17055 3580810..3581421 - 612 WP_181631500.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163569 WP_002892050.1 NZ_CP056473:3577033-3577251 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163569 NZ_CP072686:2857274-2857381 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14454.26 Da        Isoelectric Point: 5.5653

>AT163569 WP_115259201.1 NZ_CP056473:3576631-3577005 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT163569 NZ_CP072686:c2857221-2857160 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References