Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 672081..672760 Replicon chromosome
Accession NZ_CP056466
Organism Citrobacter freundii strain RHBSTW-00486

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV214_RS03315 Protein ID WP_181212950.1
Coordinates 672419..672760 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV214_RS03310 Protein ID WP_181212949.1
Coordinates 672081..672398 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV214_RS03270 667632..668465 + 834 WP_181212941.1 DUF945 domain-containing protein -
HV214_RS03275 668667..669371 + 705 WP_181212942.1 WYL domain-containing protein -
HV214_RS03280 669368..669982 + 615 WP_181212943.1 hypothetical protein -
HV214_RS03285 670072..670482 + 411 WP_181212944.1 hypothetical protein -
HV214_RS03290 670560..670796 + 237 WP_181212945.1 DUF905 domain-containing protein -
HV214_RS03295 670882..671340 + 459 WP_181212946.1 antirestriction protein -
HV214_RS03300 671349..671831 + 483 WP_181212947.1 DNA repair protein RadC -
HV214_RS03305 671840..672061 + 222 WP_181212948.1 DUF987 domain-containing protein -
HV214_RS03310 672081..672398 + 318 WP_181212949.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV214_RS03315 672419..672760 + 342 WP_181212950.1 TA system toxin CbtA family protein Toxin
HV214_RS03320 672876..673709 + 834 WP_181212951.1 DUF4942 domain-containing protein -
HV214_RS03330 674012..674518 + 507 WP_046670279.1 G/U mismatch-specific DNA glycosylase -
HV214_RS03335 674549..676546 - 1998 WP_003838090.1 TonB-dependent receptor -
HV214_RS03340 676557..677606 - 1050 WP_003846277.1 YncE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.87 Da        Isoelectric Point: 8.5163

>T163538 WP_181212950.1 NZ_CP056466:672419-672760 [Citrobacter freundii]
MKPQPATTSRAVKPCLSPVTVWQMLLTRLFEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
IWQEQSPYLRAVDILRARQATGLLRQSHNNAIR

Download         Length: 342 bp

>T163538 NZ_CP072653:c3794050-3793733 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12009.62 Da        Isoelectric Point: 7.3225

>AT163538 WP_181212949.1 NZ_CP056466:672081-672398 [Citrobacter freundii]
MTYITWGLQRNITPRLGARLVQEGNRLHYLADRGSITGKFSDAECRKLDETFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTFGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT163538 NZ_CP072653:c3793740-3793453 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References