Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 249376..250007 Replicon chromosome
Accession NZ_CP056466
Organism Citrobacter freundii strain RHBSTW-00486

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HV214_RS01190 Protein ID WP_046671263.1
Coordinates 249376..249651 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag HV214_RS01195 Protein ID WP_003837808.1
Coordinates 249648..250007 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV214_RS01180 245427..248174 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
HV214_RS01185 248174..249298 + 1125 WP_046671262.1 ABC transporter permease -
HV214_RS01190 249376..249651 + 276 WP_046671263.1 type II toxin-antitoxin system HicA family toxin Toxin
HV214_RS01195 249648..250007 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV214_RS01200 250120..250521 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
HV214_RS01205 250571..251149 - 579 WP_181212921.1 4'-phosphopantetheinyl transferase AcpT -
HV214_RS01210 251212..252261 - 1050 WP_003023393.1 AI-2E family transporter -
HV214_RS01215 252395..253612 + 1218 WP_032950436.1 MFS transporter -
HV214_RS01220 253616..254173 - 558 WP_046671264.1 DcrB family lipoprotein -
HV214_RS01225 254246..254911 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10238.90 Da        Isoelectric Point: 10.7844

>T163536 WP_046671263.1 NZ_CP056466:249376-249651 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIRWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T163536 NZ_CP072653:1829635-1829737 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT163536 WP_003837808.1 NZ_CP056466:249648-250007 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT163536 NZ_CP072653:c1829744-1829599 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References