Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4235507..4236165 Replicon chromosome
Accession NZ_CP056451
Organism Citrobacter freundii strain RHBSTW-00502

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HV221_RS20450 Protein ID WP_048216874.1
Coordinates 4235507..4235848 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV221_RS20455 Protein ID WP_181595378.1
Coordinates 4235869..4236165 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV221_RS20430 4231997..4232359 + 363 WP_032937671.1 endoribonuclease SymE -
HV221_RS20435 4232406..4233041 - 636 WP_003837147.1 HNH endonuclease -
HV221_RS20440 4233182..4234054 + 873 WP_048216872.1 HNH endonuclease -
HV221_RS20445 4234236..4235243 - 1008 WP_048216873.1 restriction endonuclease -
HV221_RS20450 4235507..4235848 - 342 WP_048216874.1 TA system toxin CbtA family protein Toxin
HV221_RS20455 4235869..4236165 - 297 WP_181595378.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV221_RS20460 4236221..4236763 - 543 WP_048216876.1 DNA repair protein RadC -
HV221_RS20465 4236776..4237219 - 444 WP_048216877.1 antirestriction protein -
HV221_RS20470 4237250..4238071 - 822 WP_048216878.1 DUF945 domain-containing protein -
HV221_RS20475 4238170..4238400 - 231 WP_048216879.1 DUF905 domain-containing protein -
HV221_RS20480 4238472..4238921 - 450 WP_048216880.1 hypothetical protein -
HV221_RS20485 4238918..4239370 - 453 WP_048216881.1 hypothetical protein -
HV221_RS20490 4239407..4239976 - 570 WP_048216882.1 hypothetical protein -
HV221_RS20495 4239976..4240680 - 705 WP_048216883.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12750.69 Da        Isoelectric Point: 8.0324

>T163516 WP_048216874.1 NZ_CP056451:c4235848-4235507 [Citrobacter freundii]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRTVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T163516 NZ_CP072630:479938-480186 [Leptospira borgpetersenii]
ATGAAGGCTTTAGTTGTAAAAATAGGTAATTCAAAAGGAATTCGGATTCCCAAAGCGGTTTTAGAAGAATGCCATATTGA
AGAAGAAGTAGATTTACTAATCGATAACAATAAATTAATTATTGTGCCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAATCAATGTCATCTAATAAAGATGATAAATTGCTTATTCCTGATTCAATAGATTTATCGGATAAGGATTGG
GAATGGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11096.48 Da        Isoelectric Point: 6.2002

>AT163516 WP_181595378.1 NZ_CP056451:c4236165-4235869 [Citrobacter freundii]
MNCNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFTCEA
DTLGSYGYVYIAVYPTHR

Download         Length: 297 bp

>AT163516 NZ_CP072630:480180-480503 [Leptospira borgpetersenii]
ATGGTGATTTCTCAATACGAAGTATATTTGATAAATTTAGATCCAACGGTCGGACATGAGATTAAAAAATCAAGACCTTG
CGTAATAATCTCACCTAATGAAATGAATAAAACTATCGGAACAATTATTATTACACCAATGACTACAAAATCTCGATCAT
ATCCAACAAGAGTCGAATTAACATTTCAAGGAAAGAAAGGCTGGATTGTGTTAGATCAAATTCGAACTGTAGATAAAATA
CGTCTGATAAAAAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGATTATAAAGGAAATGTTGGTTGA
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References