Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 256264..256895 Replicon chromosome
Accession NZ_CP056451
Organism Citrobacter freundii strain RHBSTW-00502

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag HV221_RS01180 Protein ID WP_003837806.1
Coordinates 256264..256539 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag HV221_RS01185 Protein ID WP_003837808.1
Coordinates 256536..256895 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV221_RS01170 252315..255062 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
HV221_RS01175 255062..256186 + 1125 WP_003837801.1 ABC transporter permease -
HV221_RS01180 256264..256539 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
HV221_RS01185 256536..256895 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV221_RS01190 257006..257407 - 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
HV221_RS01195 257457..258035 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
HV221_RS01200 258098..259147 - 1050 WP_003023393.1 AI-2E family transporter -
HV221_RS01205 259281..260498 + 1218 WP_048217067.1 MFS transporter -
HV221_RS01210 260502..261059 - 558 WP_003837816.1 DcrB family lipoprotein -
HV221_RS01215 261132..261797 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T163500 WP_003837806.1 NZ_CP056451:256264-256539 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T163500 NZ_CP072618:c2830038-2829790 [Leptospira borgpetersenii]
ATGAAGGCTTTAGTTGTAAAAATAGGTAATTCAAAAGGAATTCGGATTCCCAAAGCGGTTTTAGAAGAATGCCATATTGA
AGAAGAAGTAGATTTACTAATCGATAACAATAAATTAATTATTGTGCCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAATCAATGTCATCTAATAAAGATGATAAATTGCTTATTCCTGATTCAATAGATTTATCGGATAAGGATTGG
GAATGGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT163500 WP_003837808.1 NZ_CP056451:256536-256895 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT163500 NZ_CP072618:c2829796-2829473 [Leptospira borgpetersenii]
ATGGTGATTTCTCAATACGAAGTATATTTGATAAATTTAGATCCAACGGTCGGACATGAGATTAAAAAATCAAGACCTTG
CGTAATAATCTCACCTAATGAAATGAATAAAACTATCGGAACAATTATTATTACACCAATGACTACAAAATCTCGATCAT
ATCCAACAAGAGTCGAATTAACATTTCAAGGAAAGAAAGGCTGGATTGTGTTAGATCAAATTCGAACTGTAGATAAAATA
CGTCTGATAAAAAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGATTATAAAGGAAATGTTGGTTGA
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References