Detailed information of TA system TA163498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 107259..108169
• Replicon: plasmid pRHBSTW-00510_2
• Accession: NZ_CP056433
• Organism: Klebsiella pneumoniae strain RHBSTW-00510

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2A5MBW7
• Locus tag: HV225_RS27005
• Protein ID: WP_023329005.1
• Coordinates: 107259..107729 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV225_RS27010
• Protein ID: WP_023329004.1
• Coordinates: 107726..108169 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV225_RS26980	102950..103918	-	969	WP_072206835.1	IS5 family transposase	-
HV225_RS26985	104206..104454	+	249	WP_004187025.1	plasmid stabilization protein	-
HV225_RS26990	104444..104728	+	285	WP_004187019.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HV225_RS26995	104744..106087	-	1344	WP_032738442.1	ISNCY family transposase	-
HV225_RS27000	106889..107148	+	260	Protein_116	hypothetical protein	-
HV225_RS27005	107259..107729	-	471	WP_023329005.1	RES family NAD+ phosphorylase	Toxin
HV225_RS27010	107726..108169	-	444	WP_023329004.1	DUF2384 domain-containing protein	Antitoxin
HV225_RS27015	108291..108978	-	688	Protein_119	DUF4113 domain-containing protein	-
HV225_RS27020	109139..110134	-	996	WP_032738441.1	DUF2891 domain-containing protein	-
HV225_RS27025	110144..111130	-	987	Protein_121	DUF979 domain-containing protein	-
HV225_RS27030	111127..111848	-	722	Protein_122	DUF969 domain-containing protein	-
HV225_RS27035	112047..112385	+	339	WP_032738440.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla	1..206782	206782

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17459.70 Da
• Isoelectric Point: 4.4829

>T163498 WP_023329005.1 NZ_CP056433:c107729-107259 [Klebsiella pneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T163498 NZ_CP072618:c841828-841427 [Leptospira borgpetersenii]
ATGACTCAATACTTATTAGATACGAATATTTGCATTTATATAATAAACCAAAAGCCGAGATCTGTTTATAAAAAATTTAA
AAAGATCAAGTTAGAAAACATATTTATTTCATCAATTACGGAATTTGAATTAAAGTATGGTGTTCAAAAAAGTCTTCATC
TCGAAAGGAACTTAAAAATTTTAGAAGAGTTTTTAAGTTATTTGAATATTCTTTCATTTGTTAGTGAAGACGCAAATAAA
GCTGCAAAAATTCGAGTAGAATTAGACAAAGTAGGGAAACCAATCGGTCCTTTCGATCTTTTAATAGCTTCTCAAGCGTT
ATCGAATAAACTTACTCTCGTAACAAACAATGAAAAAGAGTTTACTCGGATCAAAGATATTAAAATTGCAAACTGGCTTT
AA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16477.82 Da
• Isoelectric Point: 10.2498

>AT163498 WP_023329004.1 NZ_CP056433:c108169-107726 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADSVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT163498 NZ_CP072618:c842055-841825 [Leptospira borgpetersenii]
ATGAATAAAGCTAAAATTTTTAAAAATGGGGATAGTCAAGCAATTCGTTTACCGAAAGACTATCGTTTCAAAGGCAAAGA
AGTCTATATACGAAGGGATGGAGATAATGTTATCTTAACGCCAATAAACGATGCGGTTGATCGTTTTTGGAATACGGTTA
ATAGCTTTTCTGACGATCTTATACTTGATCGAAACCAACCAAACGAGTATGGCAAACGAAATAAAATATGA

Structures

Toxin

• AlphaFold DB: A0A2A5MBW7