Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4031392..4032011 Replicon chromosome
Accession NZ_CP056432
Organism Klebsiella pneumoniae strain RHBSTW-00510

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV225_RS20100 Protein ID WP_002892050.1
Coordinates 4031793..4032011 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV225_RS20095 Protein ID WP_002892066.1
Coordinates 4031392..4031766 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV225_RS20085 4026544..4027737 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV225_RS20090 4027760..4030906 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HV225_RS20095 4031392..4031766 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV225_RS20100 4031793..4032011 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV225_RS20105 4032170..4032736 + 567 WP_002892030.1 maltose O-acetyltransferase -
HV225_RS20110 4032708..4032848 - 141 WP_004147370.1 hypothetical protein -
HV225_RS20115 4032869..4033339 + 471 WP_002892026.1 YlaC family protein -
HV225_RS20120 4033314..4034765 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
HV225_RS20125 4034866..4035564 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HV225_RS20130 4035561..4035701 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV225_RS20135 4035701..4035964 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163490 WP_002892050.1 NZ_CP056432:4031793-4032011 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163490 NZ_CP072610:1135958-1136272 [Pseudomonas wenzhouensis]
TTGTCTGCTGAGGAGCAGGAGTCTGTTGCGGTGTCAGTCCAGCTCTTGGAGGAGCGAGGCCCGTCACTTGGCTTTCCACA
CAGCAGCGGAATCAACGGCTCTCGTCACAGCCACATGCGGGAGCTGAGGACGCAGCACGAAGGCCGATCCTACAGAACGC
TGTATGCATTCGATCCCAGGCGCTCGGCTATCTTGCTGATCGATGGCGACAAGACTGGTGATGATCGTTGGTATGACATC
AACGTTCCGCTGTCTGATCGACTGTATGACGAACATCTGGAACAGCTTCGAAAGGAGGGCTTGATAGATGGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT163490 WP_002892066.1 NZ_CP056432:4031392-4031766 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT163490 NZ_CP072610:1136265-1136597 [Pseudomonas wenzhouensis]
ATGGCTAAGAAATTTGCAGAGCTGCGCGCAAAAATGGCGCCTGAGGCTCAGGCCAGGGTAGAGGCAAAAGCCCAGGAGCT
GCTTGCAGAGATGCCGCTTCATGAGCTGCGTCAGGCTCGTGGGTTGTCACAGAAGGTGCTGGCTGAGGTACTGCATGTAC
AGCAACCATCCATTGCCAAGATGGAAAAGCGTACTGACATATACATTTCCACTTTGCGTAGCCACATCGAAGCCATGGGT
GGTCAGTTGGATGTCATTGCCCGGTTTCCCGATGGTTCGGTGAAGATCAGCAATTTTTCAGACATCGAAAGCGATCTTCT
CCTGCAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References