Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 175093..175619 Replicon plasmid pRHBSTW-00515_2
Accession NZ_CP056426
Organism Klebsiella pneumoniae strain RHBSTW-00515

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV227_RS28320 Protein ID WP_000323025.1
Coordinates 175093..175380 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag HV227_RS28325 Protein ID WP_004196370.1
Coordinates 175380..175619 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV227_RS28290 170764..171081 - 318 WP_015065519.1 hypothetical protein -
HV227_RS28295 171096..171446 - 351 WP_032425551.1 hypothetical protein -
HV227_RS28300 171443..171715 - 273 WP_032425552.1 hypothetical protein -
HV227_RS28305 172571..173683 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
HV227_RS28310 173762..173920 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
HV227_RS28315 173992..175026 + 1035 Protein_190 IS481-like element ISKpn28 family transposase -
HV227_RS28320 175093..175380 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV227_RS28325 175380..175619 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV227_RS28330 175870..176235 + 366 WP_009651956.1 hypothetical protein -
HV227_RS28335 176279..177016 + 738 WP_008460272.1 HupE/UreJ family protein -
HV227_RS28340 177030..177719 + 690 WP_004196322.1 hypothetical protein -
HV227_RS28345 177750..179126 - 1377 Protein_196 chromate efflux transporter -
HV227_RS28350 179083..180060 - 978 WP_004196334.1 chromate resistance protein -
HV227_RS28355 180090..180282 + 193 Protein_198 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..220501 220501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163477 WP_000323025.1 NZ_CP056426:c175380-175093 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163477 NZ_CP072602:1462257-1462838 [Burkholderia latens]
ATGAAGCTCGATACGATTCACGCGCGGCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTTCGCAGTGGCCA
TACGTCGGCCGGGCGCGCTGAAAGCACGGCCGAACACAGCTGGCGGCTATGCCTGATGGCACTCGTGTTTGCCGATGCGC
TACCCGACGTCGACACGACGAAGCTGCTGAAGCTCTGCGTCGTGCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCTGACAAGAGCACACACGAACGCGACGACCTGCTGACGCTGACAGCCGGACTCGATCG
CGCGCTGCGCGACGAGATCGTCGCACTGTGGGACGAATATGAAGCGGCAGTCTCCCCGGAAGCACGCGCAGCGAAGGCGC
TCGACAAGCTGGAGACGATCATGCAGCACAACCAGGGCAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGATGCGGACACGCAACGCAGGATCGA
TACTCGCGACGACGGCGCGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT163477 WP_004196370.1 NZ_CP056426:c175619-175380 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT163477 NZ_CP072602:1461592-1462149 [Burkholderia latens]
ATGTGCGCGTCACCGCTTCATACTCCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACGCTGCATCGCATGAAGCAGAG
TCACGCGGCGGAGTTGTTCGGCGTTGCGCAATCGACGATCTCGCGCTGGGAGGCCGGCATCCAGCAGATGTCCGCCGACG
AGCGCGCGATGGCCGAACGGCTGCTTGCCGCGCGTCTCGATTCAGCGGGCGATCGCGCGCTCGCCCGGCTGATCGAGAGC
AGCACGTCACGCATGCATCTCGTATGCGATCTCACGCACCGTCTGCTCGCCAGTTCGCCATCGCGCGCCGCCGAGTTCTC
GCGGCCGCTGGCGACGTTGCTCGGCACGTCGCTCTGGCGGTACGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCGCGATTGCGCGGGACCGCCGAGCGTCGAATTCGCGACCGGCGCCAATGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACCTGCCGCTGGACGCGGATGATGCTGTCGGACGGCTCCGCCGCGCGACTCGTCGAAACGCTGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References