Detailed information of TA system TA163469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2714144..2715732
• Replicon: chromosome
• Accession: NZ_CP056425
• Organism: Klebsiella pneumoniae strain RHBSTW-00515

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV227_RS13660
• Protein ID: WP_048265556.1
• Coordinates: 2714144..2715466 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HV227_RS13665
• Protein ID: WP_002904790.1
• Coordinates: 2715466..2715732 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV227_RS13645	2709200..2711701	+	2502	Protein_2673	fimbrial biogenesis outer membrane usher protein	-
HV227_RS13650	2711689..2712693	+	1005	WP_048265557.1	type 1 fimbrial protein	-
HV227_RS13655	2712835..2714127	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HV227_RS13660	2714144..2715466	-	1323	WP_048265556.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV227_RS13665	2715466..2715732	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HV227_RS13670	2715998..2716324	-	327	WP_048265555.1	hydroxyisourate hydrolase	-
HV227_RS13675	2716321..2716821	-	501	WP_048265554.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HV227_RS13680	2716799..2718178	-	1380	WP_048265553.1	purine permease	-
HV227_RS13685	2718524..2719678	+	1155	WP_048265552.1	FAD-dependent urate hydroxylase HpxO	-
HV227_RS13690	2719659..2720582	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49196.52 Da
• Isoelectric Point: 7.8897

>T163469 WP_048265556.1 NZ_CP056425:c2715466-2714144 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRRLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T163469 NZ_CP072598:1547082-1547336 [Duffyella gerundensis]
ATGAACAAACGACACCAGAAAACGCTGTCAGATGTGTTTGCCCGGCCAGTTAGTGGTTCGATAAAATGGAGTGATATTGA
ATCTCTTTTTATCGCTCTCGGTGCGGCGGTTCACGAAAGGGAAGGTTCAAGGATTGCTGTACTGCTGAAAGGGCAAAAGA
AAATCTTTCACAGTCCACACTCTAGACCTACCACTGATAAGGGGGCGGTTAACTCCATTAGGGTATGGCTCGATAGCTTA
GGAATGAGATCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT163469 WP_002904790.1 NZ_CP056425:c2715732-2715466 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT163469 NZ_CP072598:1547333-1547674 [Duffyella gerundensis]
ATGAACAACACACTTAAAATCGACGGCCATTTGGCCGTCATCACCTTTGACCCTGAGATCGAAATGTTTCGTGGGGAGTT
TGTCGGCCTGAATGGTGGAGCTGACTTTTACGCTTACAGCGTCGAAGAGCTGAAAAAAGAGGGGTCAACCTCACTGGCGG
TTTTTCTCGATGAATGCCGCAAGGATGATATCGAACCTTATAAGACATTCAGCGGTAAGGTGACTACCCGCCTGACGCCA
GAACGGCATCAGGCGCTGGCCATAACTGCTCAGGCGCACGGTGTTTCTATCAATGAACTGCTTAACGAAGGCGTTGATCT
TGTCATTGAAAAACGCTCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8