Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 859473..860130 Replicon chromosome
Accession NZ_CP056425
Organism Klebsiella pneumoniae strain RHBSTW-00515

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV227_RS04370 Protein ID WP_002916310.1
Coordinates 859720..860130 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV227_RS04365 Protein ID WP_002916312.1
Coordinates 859473..859739 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV227_RS04340 854681..856114 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HV227_RS04345 856233..856961 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HV227_RS04350 857011..857322 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HV227_RS04355 857486..858145 + 660 WP_002916317.1 hemolysin III family protein -
HV227_RS04360 858244..859227 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HV227_RS04365 859473..859739 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV227_RS04370 859720..860130 + 411 WP_002916310.1 protein YgfX Toxin
HV227_RS04375 860137..860658 - 522 WP_004144730.1 flavodoxin FldB -
HV227_RS04380 860759..861655 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV227_RS04385 861678..862391 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV227_RS04390 862397..864130 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T163460 WP_002916310.1 NZ_CP056425:859720-860130 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T163460 NZ_CP072586:479860-480201 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT163460 WP_002916312.1 NZ_CP056425:859473-859739 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163460 NZ_CP072586:479630-479860 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References