Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2507622..2508258 Replicon chromosome
Accession NZ_CP056421
Organism Citrobacter sp. RHBSTW-00524

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag HV229_RS12080 Protein ID WP_049259794.1
Coordinates 2507622..2507810 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV229_RS12085 Protein ID WP_131341011.1
Coordinates 2507842..2508258 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV229_RS12060 2504400..2504630 - 231 WP_016156585.1 DUF2554 family protein -
HV229_RS12065 2504820..2504945 - 126 WP_003020230.1 DUF2474 domain-containing protein -
HV229_RS12070 2504945..2505955 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
HV229_RS12075 2505955..2507358 - 1404 WP_131350825.1 cytochrome ubiquinol oxidase subunit I -
HV229_RS12080 2507622..2507810 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
HV229_RS12085 2507842..2508258 + 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV229_RS12090 2508351..2509760 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
HV229_RS12095 2510090..2511235 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
HV229_RS12100 2511252..2512268 + 1017 WP_016153153.1 ABC transporter ATP-binding protein -
HV229_RS12105 2512269..2513213 + 945 WP_181547637.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T163442 WP_049259794.1 NZ_CP056421:2507622-2507810 [Citrobacter sp. RHBSTW-00524]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

>T163442 NZ_CP072566:2614322-2614429 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT163442 WP_131341011.1 NZ_CP056421:2507842-2508258 [Citrobacter sp. RHBSTW-00524]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT163442 NZ_CP072566:c2614272-2614209 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References