Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
Location | 1565548..1566212 | Replicon | chromosome |
Accession | NZ_CP056421 | ||
Organism | Citrobacter sp. RHBSTW-00524 |
Toxin (Protein)
Gene name | ykfI | Uniprot ID | A0A157QTP3 |
Locus tag | HV229_RS07440 | Protein ID | WP_007869731.1 |
Coordinates | 1565548..1565874 (-) | Length | 109 a.a. |
Antitoxin (Protein)
Gene name | yfjZ | Uniprot ID | A0A0M7FI99 |
Locus tag | HV229_RS07445 | Protein ID | WP_007869729.1 |
Coordinates | 1565895..1566212 (-) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV229_RS07425 | 1561360..1563258 | + | 1899 | WP_016153885.1 | methyl-accepting chemotaxis protein | - |
HV229_RS07430 | 1563325..1564356 | - | 1032 | WP_181547690.1 | isoaspartyl peptidase/L-asparaginase | - |
HV229_RS07435 | 1564674..1565300 | + | 627 | WP_181547176.1 | DNA-binding protein | - |
HV229_RS07440 | 1565548..1565874 | - | 327 | WP_007869731.1 | TA system toxin CbtA family protein | Toxin |
HV229_RS07445 | 1565895..1566212 | - | 318 | WP_007869729.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HV229_RS07450 | 1566226..1566453 | - | 228 | WP_013098172.1 | DUF987 domain-containing protein | - |
HV229_RS07455 | 1566462..1566938 | - | 477 | WP_013098171.1 | RadC family protein | - |
HV229_RS07460 | 1566954..1567412 | - | 459 | WP_069729801.1 | antirestriction protein | - |
HV229_RS07465 | 1567516..1567755 | - | 240 | WP_007869725.1 | DUF905 domain-containing protein | - |
HV229_RS07470 | 1567779..1568600 | - | 822 | WP_039390904.1 | DUF945 domain-containing protein | - |
HV229_RS07475 | 1568787..1568987 | - | 201 | WP_069729807.1 | permease | - |
HV229_RS07480 | 1569067..1569339 | - | 273 | WP_007869719.1 | hypothetical protein | - |
HV229_RS07485 | 1569396..1570133 | - | 738 | WP_069729802.1 | WYL domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12299.25 Da Isoelectric Point: 8.9951
>T163440 WP_007869731.1 NZ_CP056421:c1565874-1565548 [Citrobacter sp. RHBSTW-00524]
MKTLPATTQRAAKPCLSPVAVWQMLLARLLEQHYGLTINDTPFSDEVVIQQHIDAGITLSDAVNFLVEKYELVRIDRKGF
RWQEQSPYLRAVDILRARQAIGLLRGSH
MKTLPATTQRAAKPCLSPVAVWQMLLARLLEQHYGLTINDTPFSDEVVIQQHIDAGITLSDAVNFLVEKYELVRIDRKGF
RWQEQSPYLRAVDILRARQAIGLLRGSH
Download Length: 327 bp
>T163440 NZ_CP072566:2613252-2613359 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11917.60 Da Isoelectric Point: 7.0264
>AT163440 WP_007869729.1 NZ_CP056421:c1566212-1565895 [Citrobacter sp. RHBSTW-00524]
MTHIIWGLQRAITPRLGARLVQEGNRLHYLADRASITGMFSDAECRKLDDTFPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR
MTHIIWGLQRAITPRLGARLVQEGNRLHYLADRASITGMFSDAECRKLDDTFPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT163440 NZ_CP072566:c2613205-2613139 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A157QTP3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M7FI99 |