Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1565548..1566212 Replicon chromosome
Accession NZ_CP056421
Organism Citrobacter sp. RHBSTW-00524

Toxin (Protein)


Gene name ykfI Uniprot ID A0A157QTP3
Locus tag HV229_RS07440 Protein ID WP_007869731.1
Coordinates 1565548..1565874 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0M7FI99
Locus tag HV229_RS07445 Protein ID WP_007869729.1
Coordinates 1565895..1566212 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV229_RS07425 1561360..1563258 + 1899 WP_016153885.1 methyl-accepting chemotaxis protein -
HV229_RS07430 1563325..1564356 - 1032 WP_181547690.1 isoaspartyl peptidase/L-asparaginase -
HV229_RS07435 1564674..1565300 + 627 WP_181547176.1 DNA-binding protein -
HV229_RS07440 1565548..1565874 - 327 WP_007869731.1 TA system toxin CbtA family protein Toxin
HV229_RS07445 1565895..1566212 - 318 WP_007869729.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV229_RS07450 1566226..1566453 - 228 WP_013098172.1 DUF987 domain-containing protein -
HV229_RS07455 1566462..1566938 - 477 WP_013098171.1 RadC family protein -
HV229_RS07460 1566954..1567412 - 459 WP_069729801.1 antirestriction protein -
HV229_RS07465 1567516..1567755 - 240 WP_007869725.1 DUF905 domain-containing protein -
HV229_RS07470 1567779..1568600 - 822 WP_039390904.1 DUF945 domain-containing protein -
HV229_RS07475 1568787..1568987 - 201 WP_069729807.1 permease -
HV229_RS07480 1569067..1569339 - 273 WP_007869719.1 hypothetical protein -
HV229_RS07485 1569396..1570133 - 738 WP_069729802.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12299.25 Da        Isoelectric Point: 8.9951

>T163440 WP_007869731.1 NZ_CP056421:c1565874-1565548 [Citrobacter sp. RHBSTW-00524]
MKTLPATTQRAAKPCLSPVAVWQMLLARLLEQHYGLTINDTPFSDEVVIQQHIDAGITLSDAVNFLVEKYELVRIDRKGF
RWQEQSPYLRAVDILRARQAIGLLRGSH

Download         Length: 327 bp

>T163440 NZ_CP072566:2613252-2613359 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11917.60 Da        Isoelectric Point: 7.0264

>AT163440 WP_007869729.1 NZ_CP056421:c1566212-1565895 [Citrobacter sp. RHBSTW-00524]
MTHIIWGLQRAITPRLGARLVQEGNRLHYLADRASITGMFSDAECRKLDDTFPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT163440 NZ_CP072566:c2613205-2613139 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A157QTP3

Antitoxin

Source ID Structure
AlphaFold DB A0A0M7FI99

References