Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4863720..4864336 | Replicon | chromosome |
Accession | NZ_CP056409 | ||
Organism | Citrobacter sp. RHBSTW-00535 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | HV232_RS23155 | Protein ID | WP_016155182.1 |
Coordinates | 4863720..4864094 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | R8WIS4 |
Locus tag | HV232_RS23160 | Protein ID | WP_016155181.1 |
Coordinates | 4864094..4864336 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV232_RS23140 | 4861223..4862125 | + | 903 | WP_003028691.1 | formate dehydrogenase O subunit beta | - |
HV232_RS23145 | 4862122..4862757 | + | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
HV232_RS23150 | 4862754..4863683 | + | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
HV232_RS23155 | 4863720..4864094 | - | 375 | WP_016155182.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HV232_RS23160 | 4864094..4864336 | - | 243 | WP_016155181.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
HV232_RS23165 | 4864542..4865471 | + | 930 | WP_094169176.1 | alpha/beta hydrolase | - |
HV232_RS23170 | 4865556..4865867 | + | 312 | WP_047357780.1 | type II toxin-antitoxin system HigB family toxin | - |
HV232_RS23175 | 4865864..4866316 | + | 453 | WP_047357781.1 | helix-turn-helix domain-containing protein | - |
HV232_RS23180 | 4866334..4867275 | - | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
HV232_RS23185 | 4867320..4867757 | - | 438 | WP_016157874.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
HV232_RS23190 | 4867754..4868626 | - | 873 | WP_019077938.1 | virulence factor BrkB family protein | - |
HV232_RS23195 | 4868620..4869219 | - | 600 | WP_016157873.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13678.84 Da Isoelectric Point: 8.5373
>T163436 WP_016155182.1 NZ_CP056409:c4864094-4863720 [Citrobacter sp. RHBSTW-00535]
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL
Download Length: 375 bp
>T163436 NZ_CP072566:1988180-1988283 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 81 a.a. Molecular weight: 9437.72 Da Isoelectric Point: 4.3331
>AT163436 WP_016155181.1 NZ_CP056409:c4864336-4864094 [Citrobacter sp. RHBSTW-00535]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW
Download Length: 243 bp
>AT163436 NZ_CP072566:c1988321-1988050 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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