Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4863720..4864336 Replicon chromosome
Accession NZ_CP056409
Organism Citrobacter sp. RHBSTW-00535

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV232_RS23155 Protein ID WP_016155182.1
Coordinates 4863720..4864094 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R8WIS4
Locus tag HV232_RS23160 Protein ID WP_016155181.1
Coordinates 4864094..4864336 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV232_RS23140 4861223..4862125 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
HV232_RS23145 4862122..4862757 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
HV232_RS23150 4862754..4863683 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
HV232_RS23155 4863720..4864094 - 375 WP_016155182.1 type II toxin-antitoxin system VapC family toxin Toxin
HV232_RS23160 4864094..4864336 - 243 WP_016155181.1 ribbon-helix-helix domain-containing protein Antitoxin
HV232_RS23165 4864542..4865471 + 930 WP_094169176.1 alpha/beta hydrolase -
HV232_RS23170 4865556..4865867 + 312 WP_047357780.1 type II toxin-antitoxin system HigB family toxin -
HV232_RS23175 4865864..4866316 + 453 WP_047357781.1 helix-turn-helix domain-containing protein -
HV232_RS23180 4866334..4867275 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
HV232_RS23185 4867320..4867757 - 438 WP_016157874.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV232_RS23190 4867754..4868626 - 873 WP_019077938.1 virulence factor BrkB family protein -
HV232_RS23195 4868620..4869219 - 600 WP_016157873.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-113)

Antitoxin

(13-47)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13678.84 Da        Isoelectric Point: 8.5373

>T163436 WP_016155182.1 NZ_CP056409:c4864094-4863720 [Citrobacter sp. RHBSTW-00535]
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL

Download         Length: 375 bp

>T163436 NZ_CP072566:1988180-1988283 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.72 Da        Isoelectric Point: 4.3331

>AT163436 WP_016155181.1 NZ_CP056409:c4864336-4864094 [Citrobacter sp. RHBSTW-00535]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW

Download         Length: 243 bp

>AT163436 NZ_CP072566:c1988321-1988050 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB R8WIS4

References