Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/ElaA-DUF1778 |
| Location | 49698..50495 | Replicon | plasmid pRHBSTW-00570_3 |
| Accession | NZ_CP056401 | ||
| Organism | Citrobacter sp. RHBSTW-00570 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | HV237_RS25390 | Protein ID | WP_172754447.1 |
| Coordinates | 49992..50495 (+) | Length | 168 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | A0A5D4NAG3 |
| Locus tag | HV237_RS25385 | Protein ID | WP_016582626.1 |
| Coordinates | 49698..49967 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV237_RS25365 | 45584..46309 | - | 726 | WP_130715040.1 | hypothetical protein | - |
| HV237_RS25370 | 46501..48204 | - | 1704 | WP_131405960.1 | hypothetical protein | - |
| HV237_RS25375 | 48253..48606 | - | 354 | WP_160859104.1 | hypothetical protein | - |
| HV237_RS25380 | 48612..49277 | - | 666 | WP_023315962.1 | AAA family ATPase | - |
| HV237_RS25385 | 49698..49967 | + | 270 | WP_016582626.1 | DUF1778 domain-containing protein | Antitoxin |
| HV237_RS25390 | 49992..50495 | + | 504 | WP_172754447.1 | GNAT family N-acetyltransferase | Toxin |
| HV237_RS25395 | 50524..50730 | - | 207 | WP_165501435.1 | hypothetical protein | - |
| HV237_RS25400 | 50681..50932 | - | 252 | WP_000147960.1 | hypothetical protein | - |
| HV237_RS25405 | 50934..51626 | - | 693 | WP_006812500.1 | membrane protein | - |
| HV237_RS25410 | 51640..51963 | - | 324 | WP_000064173.1 | hypothetical protein | - |
| HV237_RS25415 | 52038..52826 | - | 789 | WP_110921389.1 | receptor-recognizing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..119726 | 119726 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 168 a.a. Molecular weight: 18603.30 Da Isoelectric Point: 8.8869
>T163420 WP_172754447.1 NZ_CP056401:49992-50495 [Citrobacter sp. RHBSTW-00570]
MFSAQAVYDFSGFDCGEPSLNDFLQNRLVQQHNGRILRGYLLLTKDPVPKVKGFYTLSGSCFARQTLPSNTQKRKIPYAD
APSVTLGRLAIDISLQKQGYGEVLVTHALKVVYQASRAVGIYALFVDALNQSAMQFYQKFGFIPLTGANANSLFYPTKSI
EELFETE
MFSAQAVYDFSGFDCGEPSLNDFLQNRLVQQHNGRILRGYLLLTKDPVPKVKGFYTLSGSCFARQTLPSNTQKRKIPYAD
APSVTLGRLAIDISLQKQGYGEVLVTHALKVVYQASRAVGIYALFVDALNQSAMQFYQKFGFIPLTGANANSLFYPTKSI
EELFETE
Download Length: 504 bp
>T163420 NZ_CP072565:2676810-2676917 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10113.57 Da Isoelectric Point: 5.8580
>AT163420 WP_016582626.1 NZ_CP056401:49698-49967 [Citrobacter sp. RHBSTW-00570]
MSALKKQRIDLRLTDDDKSMIEEAAAMTNQTITQFMVASASERAAEVIEQHRRLILSEESWNLVMDAISNPPAPNDRLKR
AAKRLQSME
MSALKKQRIDLRLTDDDKSMIEEAAAMTNQTITQFMVASASERAAEVIEQHRRLILSEESWNLVMDAISNPPAPNDRLKR
AAKRLQSME
Download Length: 270 bp
>AT163420 NZ_CP072565:c2676763-2676697 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|