Detailed information of TA system TA163416

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4618719..4619474
• Replicon: chromosome
• Accession: NZ_CP056399
• Organism: Citrobacter sp. RHBSTW-00570

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A7L6ILI8
• Locus tag: HV237_RS21975
• Protein ID: WP_047359063.1
• Coordinates: 4619097..4619474 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV237_RS21970
• Protein ID: WP_162906152.1
• Coordinates: 4618719..4619045 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV237_RS21930	4613943..4614764	+	822	WP_032751326.1	DUF945 domain-containing protein	-
HV237_RS21935	4614980..4615681	+	702	WP_047359069.1	WYL domain-containing protein	-
HV237_RS21940	4615864..4616559	+	696	WP_047359068.1	hypothetical protein	-
HV237_RS21945	4616581..4617054	+	474	WP_052951289.1	hypothetical protein	-
HV237_RS21950	4617132..4617371	+	240	WP_047359067.1	DUF905 domain-containing protein	-
HV237_RS21955	4617468..4617929	+	462	WP_047359066.1	antirestriction protein	-
HV237_RS21960	4617941..4618420	+	480	WP_047359065.1	DNA repair protein RadC	-
HV237_RS21965	4618441..4618662	+	222	WP_000691982.1	DUF987 domain-containing protein	-
HV237_RS21970	4618719..4619045	+	327	WP_162906152.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV237_RS21975	4619097..4619474	+	378	WP_047359063.1	TA system toxin CbtA family protein	Toxin
HV237_RS21980	4619471..4619962	+	492	WP_047359062.1	hypothetical protein	-
HV237_RS21985	4619991..4620194	+	204	WP_047359061.1	DUF957 domain-containing protein	-
HV237_RS21990	4620273..4621121	+	849	WP_047359060.1	DUF4942 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-110)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14078.86 Da
• Isoelectric Point: 7.0606

>T163416 WP_047359063.1 NZ_CP056399:4619097-4619474 [Citrobacter sp. RHBSTW-00570]
VQTQPLSSTHETSPRPSPVDIWQHLLNHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
SADTQSPLIGSIDILRARKATGLMTRHGYRPVTDLITGKYKKEQQ

Nucleotide

• Length: 378 bp

>T163416 NZ_CP072565:2051738-2051841 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11955.62 Da
• Isoelectric Point: 6.9554

>AT163416 WP_162906152.1 NZ_CP056399:4618719-4619045 [Citrobacter sp. RHBSTW-00570]
ITEPWWGLKRSITPCFGARLVQEGNRLHYLGDRASIAGTFSDADLRHLDQAFPVQLKQLELMLVSGELNPRHQHCVTLYS
KGLTCEADSLGSHGYVYIAIYPTPAATA

Nucleotide

• Length: 327 bp

>AT163416 NZ_CP072565:c2051879-2051608 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A7L6ILI8