Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3762555..3763175 Replicon chromosome
Accession NZ_CP056399
Organism Citrobacter sp. RHBSTW-00570

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV237_RS17930 Protein ID WP_002892050.1
Coordinates 3762957..3763175 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag HV237_RS17925 Protein ID WP_003021733.1
Coordinates 3762555..3762929 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV237_RS17915 3757702..3758895 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV237_RS17920 3758918..3762067 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
HV237_RS17925 3762555..3762929 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
HV237_RS17930 3762957..3763175 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV237_RS17935 3763356..3763907 + 552 WP_016152072.1 maltose O-acetyltransferase -
HV237_RS17940 3764024..3764494 + 471 WP_016152071.1 YlaC family protein -
HV237_RS17945 3764573..3764713 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HV237_RS17950 3764715..3764975 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
HV237_RS17955 3765164..3766717 + 1554 WP_047358017.1 EAL domain-containing protein -
HV237_RS17960 3766769..3767122 - 354 WP_003831033.1 DUF1428 family protein -
HV237_RS17965 3767187..3767816 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T163414 WP_002892050.1 NZ_CP056399:3762957-3763175 [Citrobacter sp. RHBSTW-00570]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T163414 NZ_CP072565:1876854-1877105 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT163414 WP_003021733.1 NZ_CP056399:3762555-3762929 [Citrobacter sp. RHBSTW-00570]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT163414 NZ_CP072565:1877102-1877356 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References