Detailed information of TA system TA163404

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1314087..1314754
• Replicon: chromosome
• Accession: NZ_CP056399
• Organism: Citrobacter sp. RHBSTW-00570

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV237_RS06270
• Protein ID: WP_047358936.1
• Coordinates: 1314087..1314416 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV237_RS06275
• Protein ID: WP_047358935.1
• Coordinates: 1314437..1314754 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV237_RS06245	1309765..1310550	+	786	Protein_1223	tail fiber protein	-
HV237_RS06250	1310550..1311131	+	582	Protein_1224	tail fiber assembly protein	-
HV237_RS06255	1311560..1312591	+	1032	WP_046092923.1	IS630-like element ISEc33 family transposase	-
HV237_RS06260	1312597..1313130	-	534	WP_181541751.1	3-deoxy-D-manno-oct-2-ulosonate III transferase WaaZ	-
HV237_RS06265	1313170..1313430	-	261	WP_047358937.1	helix-turn-helix domain-containing protein	-
HV237_RS06270	1314087..1314416	-	330	WP_047358936.1	TA system toxin CbtA family protein	Toxin
HV237_RS06275	1314437..1314754	-	318	WP_047358935.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV237_RS06280	1314773..1314994	-	222	WP_047358934.1	DUF987 domain-containing protein	-
HV237_RS06285	1315003..1315485	-	483	WP_032238502.1	DNA repair protein RadC	-
HV237_RS06290	1315494..1315946	-	453	WP_047358933.1	antirestriction protein	-
HV237_RS06295	1316032..1316268	-	237	WP_047358932.1	DUF905 domain-containing protein	-
HV237_RS06300	1316346..1316756	-	411	WP_047358931.1	hypothetical protein	-
HV237_RS06305	1316821..1317258	-	438	WP_038434461.1	hypothetical protein	-
HV237_RS06310	1317300..1317836	-	537	WP_047358930.1	DUF4339 domain-containing protein	-
HV237_RS06315	1317862..1318572	-	711	WP_047358929.1	DeoR family transcriptional regulator	-
HV237_RS06320	1318781..1319605	-	825	WP_047358928.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1309765..1319605	9840
	-	flank	IS/Tn	-	-	1311560..1312591	1031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12344.43 Da
• Isoelectric Point: 9.5732

>T163404 WP_047358936.1 NZ_CP056399:c1314416-1314087 [Citrobacter sp. RHBSTW-00570]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSSGLLKTNVK

Nucleotide

• Length: 330 bp

>T163404 NZ_CP072564:c3631611-3630682 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCTATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACAGTAAA
CCGGGGATTACCGCGATCCGACAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCAGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGTCGGTGTGCGAACGTGTGGAAATGGAGT
ATGGTTTCACCACTATGAGTGTCGTTTCTCTGGCGGATCTTTATGGCGGTAAAATCTGCGCGGCGCTTGATCGTCAACAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTCCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCGAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGGTGCTAAAAGATAAAAATCCTGCGAAGT
ATGTGGCGGCGGTGAGTAAGCTGGAGAGGGTTCTGGAGCAGTATTCTTAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11837.43 Da
• Isoelectric Point: 6.8407

>AT163404 WP_047358935.1 NZ_CP056399:c1314754-1314437 [Citrobacter sp. RHBSTW-00570]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPRHARCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT163404 NZ_CP072564:c3632380-3631598 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGTACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGTCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTAA
CGCCATTTACCACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGCCCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTCTATCTTGCCCGGCGTAATGGACATCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTTCGGGAAAGCGGCAAATCATACCCGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA