Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1314087..1314754 Replicon chromosome
Accession NZ_CP056399
Organism Citrobacter sp. RHBSTW-00570

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HV237_RS06270 Protein ID WP_047358936.1
Coordinates 1314087..1314416 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV237_RS06275 Protein ID WP_047358935.1
Coordinates 1314437..1314754 (-) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV237_RS06245 1309765..1310550 + 786 Protein_1223 tail fiber protein -
HV237_RS06250 1310550..1311131 + 582 Protein_1224 tail fiber assembly protein -
HV237_RS06255 1311560..1312591 + 1032 WP_046092923.1 IS630-like element ISEc33 family transposase -
HV237_RS06260 1312597..1313130 - 534 WP_181541751.1 3-deoxy-D-manno-oct-2-ulosonate III transferase WaaZ -
HV237_RS06265 1313170..1313430 - 261 WP_047358937.1 helix-turn-helix domain-containing protein -
HV237_RS06270 1314087..1314416 - 330 WP_047358936.1 TA system toxin CbtA family protein Toxin
HV237_RS06275 1314437..1314754 - 318 WP_047358935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV237_RS06280 1314773..1314994 - 222 WP_047358934.1 DUF987 domain-containing protein -
HV237_RS06285 1315003..1315485 - 483 WP_032238502.1 DNA repair protein RadC -
HV237_RS06290 1315494..1315946 - 453 WP_047358933.1 antirestriction protein -
HV237_RS06295 1316032..1316268 - 237 WP_047358932.1 DUF905 domain-containing protein -
HV237_RS06300 1316346..1316756 - 411 WP_047358931.1 hypothetical protein -
HV237_RS06305 1316821..1317258 - 438 WP_038434461.1 hypothetical protein -
HV237_RS06310 1317300..1317836 - 537 WP_047358930.1 DUF4339 domain-containing protein -
HV237_RS06315 1317862..1318572 - 711 WP_047358929.1 DeoR family transcriptional regulator -
HV237_RS06320 1318781..1319605 - 825 WP_047358928.1 DUF945 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1309765..1319605 9840
- flank IS/Tn - - 1311560..1312591 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-108)

Antitoxin

(5-104)


Sequences


Toxin        


Download         Length: 110 a.a.        Molecular weight: 12344.43 Da        Isoelectric Point: 9.5732

>T163404 WP_047358936.1 NZ_CP056399:c1314416-1314087 [Citrobacter sp. RHBSTW-00570]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSSGLLKTNVK

Download         Length: 330 bp

>T163404 NZ_CP072564:c3631611-3630682 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCTATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACAGTAAA
CCGGGGATTACCGCGATCCGACAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCAGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGTCGGTGTGCGAACGTGTGGAAATGGAGT
ATGGTTTCACCACTATGAGTGTCGTTTCTCTGGCGGATCTTTATGGCGGTAAAATCTGCGCGGCGCTTGATCGTCAACAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTCCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCGAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGGTGCTAAAAGATAAAAATCCTGCGAAGT
ATGTGGCGGCGGTGAGTAAGCTGGAGAGGGTTCTGGAGCAGTATTCTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11837.43 Da        Isoelectric Point: 6.8407

>AT163404 WP_047358935.1 NZ_CP056399:c1314754-1314437 [Citrobacter sp. RHBSTW-00570]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPRHARCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT163404 NZ_CP072564:c3632380-3631598 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGTACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGTCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTAA
CGCCATTTACCACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGCCCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTCTATCTTGCCCGGCGTAATGGACATCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTTCGGGAAAGCGGCAAATCATACCCGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References