163402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 942714..943368 Replicon chromosome
Accession NZ_CP056399
Organism Citrobacter sp. RHBSTW-00570

Toxin (Protein)


Gene name cptA Uniprot ID A0A7L6TYP6
Locus tag HV237_RS04530 Protein ID WP_047357821.1
Coordinates 942961..943368 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag HV237_RS04525 Protein ID WP_016154349.1
Coordinates 942714..942980 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV237_RS04500 937927..939360 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
HV237_RS04505 939481..940209 - 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
HV237_RS04510 940262..940573 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
HV237_RS04515 940737..941396 + 660 WP_016154351.1 hemolysin III family protein -
HV237_RS04520 941476..942456 - 981 WP_047357823.1 tRNA-modifying protein YgfZ -
HV237_RS04525 942714..942980 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
HV237_RS04530 942961..943368 + 408 WP_047357821.1 protein YgfX Toxin
HV237_RS04535 943469..943990 - 522 WP_016154347.1 flavodoxin FldB -
HV237_RS04540 944104..945000 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
HV237_RS04545 945024..945737 + 714 WP_047357820.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV237_RS04550 945743..947476 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15878.67 Da        Isoelectric Point: 11.5023

>T163402 WP_047357821.1 NZ_CP056399:942961-943368 [Citrobacter sp. RHBSTW-00570]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQARQG

Download         Length: 408 bp

>T163402 NZ_CP072564:2677866-2677973 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT163402 WP_016154349.1 NZ_CP056399:942714-942980 [Citrobacter sp. RHBSTW-00570]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163402 NZ_CP072564:c2677816-2677753 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYP6

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References