Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 711381..712134 Replicon chromosome
Accession NZ_CP056399
Organism Citrobacter sp. RHBSTW-00570

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag HV237_RS03425 Protein ID WP_025799003.1
Coordinates 711757..712134 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag HV237_RS03420 Protein ID WP_072269511.1
Coordinates 711381..711707 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV237_RS03400 706798..709944 + 3147 WP_181541729.1 AIDA repeat-containing protein -
HV237_RS03405 710167..710598 + 432 WP_088903392.1 antirestriction protein -
HV237_RS03410 710610..711089 + 480 WP_025798999.1 DNA repair protein RadC -
HV237_RS03415 711103..711324 + 222 WP_045888217.1 DUF987 domain-containing protein -
HV237_RS03420 711381..711707 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV237_RS03425 711757..712134 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
HV237_RS03430 712131..712622 + 492 WP_045888216.1 hypothetical protein -
HV237_RS03435 712651..712854 + 204 WP_025799007.1 DUF957 domain-containing protein -
HV237_RS03440 712936..713781 + 846 WP_025799009.1 DUF4942 domain-containing protein -
HV237_RS03450 714085..714591 + 507 WP_047358660.1 G/U mismatch-specific DNA glycosylase -
HV237_RS03455 714637..716481 - 1845 WP_016154549.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T163401 WP_025799003.1 NZ_CP056399:711757-712134 [Citrobacter sp. RHBSTW-00570]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T163401 NZ_CP072564:2677331-2677438 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT163401 WP_072269511.1 NZ_CP056399:711381-711707 [Citrobacter sp. RHBSTW-00570]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT163401 NZ_CP072564:c2677284-2677218 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References