Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4542625..4543210 Replicon chromosome
Accession NZ_CP056395
Organism Citrobacter freundii strain RHBSTW-00589

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HV241_RS21430 Protein ID WP_135912739.1
Coordinates 4542625..4542939 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HV241_RS21435 Protein ID WP_115259723.1
Coordinates 4542932..4543210 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV241_RS21405 4538739..4540319 + 1581 WP_181624782.1 RNA repair transcriptional activator RtcR -
HV241_RS21410 4540424..4540696 + 273 WP_096758747.1 DUF3811 domain-containing protein -
HV241_RS21415 4540693..4541568 - 876 WP_181506340.1 23S rRNA pseudouridine(2604) synthase RluF -
HV241_RS21420 4541819..4542136 - 318 WP_181624783.1 CcdB family protein -
HV241_RS21425 4542136..4542429 - 294 WP_117343618.1 type II toxin-antitoxin system CcdA family antitoxin -
HV241_RS21430 4542625..4542939 + 315 WP_135912739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV241_RS21435 4542932..4543210 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HV241_RS21440 4543322..4544011 + 690 WP_115259724.1 dipeptidase PepE -
HV241_RS21445 4544140..4545771 - 1632 WP_117343624.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11969.88 Da        Isoelectric Point: 9.5570

>T163399 WP_135912739.1 NZ_CP056395:4542625-4542939 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T163399 NZ_CP072564:c2489234-2489058 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT163399 WP_115259723.1 NZ_CP056395:4542932-4543210 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT163399 NZ_CP072564:c2489012-2488596 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References